What does the aquaculture industry’s “resistance to the ban” mean?

The "antibiotic ban" for aquaculture is the recent announcement No. 2292 issued by the People's Republic of China and the Ministry of Agriculture, which bans the use of Class 4 antibiotics in food-producing animals. It can be said that the "no resistance order" has been officially issued. Based on the content of the announcement and my country’s veterinary drug information published by the state, this journal compiled specific data: As soon as this order is issued, 5,089 veterinary drug approval numbers will be abolished (including those newly approved in 2015), involving 1,333 veterinary drug companies (also It affects 66% of the veterinary drug manufacturing companies, 2/3 of the companies!), and another characteristic is that half of the canceled approval numbers are concentrated in 20% of the companies, and the most one company has had 22 approval numbers revoked. . According to data estimates from the "Veterinary Drug Industry Development Report (2013)", the abolished products freed up 2.483 billion yuan of antibiotic preparation market space and 996 million yuan of antibiotic raw material market space. In addition, more sales companies will be involved, and the prescriptions of commonly used drugs in the national breeding industry need to be changed!

Mainly including:

1. The strict introduction of the "anti-antibiotic order"

In the breeding industry, the use of antibiotics is a controversial issue. Animals, humans It is not uncommon for pathogens to develop drug resistance. While the breeding industry is still discussing whether to ban "antibiotic feeding", the Ministry of Agriculture has issued an announcement directly banning the use of four types of "antibiotics" in food animals.

“In order to ensure the quality and safety of animal products and public health and safety, the Ministry of Agriculture organized and carried out safety evaluation work on some veterinary drugs. After evaluation, it was believed that lomefloxacin, pefloxacin, and oxyfloxacin The various salts, esters and various preparations of the four raw materials of floxacin and norfloxacin may cause harm to the breeding industry and human health or have potential risks. According to Article 69 of the "Regulations on the Administration of Veterinary Drugs", we The Ministry of Agriculture has decided to stop the use of four veterinary drugs, lomefloxacin, pefloxacin, ofloxacin and norfloxacin in food animals, and revoke the relevant veterinary drug product approval numbers. "

You are still discussing. Are antibiotics added during livestock and poultry breeding? Read the policy clearly! These four types of antibiotics commonly used by humans cannot be used not only during breeding, but also during treatment! All related veterinary drug products will be discontinued and all approval numbers will be invalidated (including those newly approved in 2015)!

2. The scientific pertinence of the "antibiotic ban"

Although this "antibiotic ban" bans four types of antibiotics in one step, it does have very strict rules. It’s scientific and targeted.

2.1 Four types of antibiotics commonly used for humans and animals

The four antibiotics lomefloxacin, pefloxacin, ofloxacin and norfloxacin all belong to the third generation. Quinolones are basic drugs of the fluoroquinolone class, which have strong antibacterial effects and good pharmacokinetic effects. They are widely used for various infections caused by sensitive strains and occupy an important position in human medical treatment. If drug-resistant strains develop when food animals are widely used, it will cause great harm to humans. This potential threat cannot be ignored. Antibiotics are gradually banned in food animals in other countries. This "anti-drug ban" targets these four types of drugs, and is not one-size-fits-all. Other drugs can still be substituted during animal medical treatment.

2.2 Food animals and non-food animals are treated separately

We can note that this time the "prohibition order" specifically states "food animals" and "non-food animals" "(For example: companion animals, draft animals, competition animals, military and police animals, etc.) Treat them differently, especially companion animals (what we often call "pets"). Their breeding, diagnosis and treatment purposes and meanings are different, and it is policy and human nature to allow different medications. The embodiment of culture and science.

The differential treatment of "food animals" and "non-food animals" also affects the changes to the instructions for this type of product. If "non-food animals" are used in time, they must be approved and must be within the "scope of use" ” noted in.

2.3 A certain buffer period is given

The description of this "anti-resistance order" states that "from December 31, 2015, the production of lomefloxacin for food animals will be stopped. The veterinary drug product approval numbers of the relevant companies involved in the various salts, esters and various preparations of the four APIs, pefloxacin, ofloxacin and norfloxacin, will be revoked at the same time before December 31, 2015. The products produced can be circulated and used before December 31, 2016. "From December 31, 2016, the operation and use will be stopped."

”

This has given veterinary drug manufacturers, distribution companies and breeding companies a buffer period, allowing them to digest raw materials and products in stock and reduce losses.

In fact, as early as 2009 In 2017, the Ministry of Agriculture has begun to gradually abolish the approval numbers of these four types of antibiotic-related products, so the issuance of this ban is not sudden.

3. The breeding industry and the veterinary drug industry must face changes

The development of the breeding industry directly affects national health and economic development. "No antibiotics" is the general trend. The breeding industry, feed industry, veterinary medicine industry and related industries must adapt to the development of the trend or they will be eliminated as the times develop. Being backward has disadvantages. Many jobs become history every year, just like many species become extinct.

Production and sales companies cease production and sales, and veterinary prescriptions change (many commonly used drugs contain or contain these four ingredients). , is a direct change of this "ban", but it may be a prelude. Based on the previous abolition of veterinary drug approval numbers, it is unknown whether there will be a gradual and complete ban on food animals.

4. Seize the opportunity to develop

Many companies may suffer losses due to this "ban", but some companies have already started to prepare. This ban is equivalent to a rare opportunity.

4.1 Provides a stage for more products

There are already many alternatives to antibiotics on the market. Some manufacturers (Sea Sea Life) already have mature shrimp synbiotics, red bacteria corps, immune male soldiers, intestinal gills Fortress, the probiotics, probiotics, enzyme preparations, and peptide preparations products are undoubtedly a huge impetus for product promotion and sales.

The market prospects for these four types of drugs are huge! Rapid detection products will also have a broad market.

4.2 The direction of new products - the development of antibiotics for food animals

In addition to antibiotic substitutes, antibiotics for food animals can also be used in product development. direction, which opens up a new world for scientific research and market.

4.3 The gospel of immune products - "prevention" has become more important

There are many alternative products for antibiotic feeding. However, the treatment of some livestock and poultry diseases inevitably requires antibiotics. The best way to reduce or avoid the use of drugs is to prevent diseases. Our magazine "China Animal Health Care" has always adhered to the concept of "treating diseases before they occur". Healthy breeding and prevention are more important than cure. The most commonly used method in the first step of prevention is vaccine immunity. The "ban on vaccination" will make breeding companies pay more attention to the immune effect, which is undoubtedly a great opportunity for vaccine companies to show the strength of their products!

The above, This brief introduction to the new policy is just an introduction. More friends are welcome to express your views.

The original text of the "No Resistance Order" announcement is as follows:

The Ministry of Agriculture of the People's Republic of China and the People's Republic of China Announcement No. 2292

In order to ensure the quality and safety of animal products and public health and safety, our Ministry has organized and carried out safety evaluation work on some veterinary drugs. After evaluation, it is believed that lomefloxacin and pefloxacin. The various salts, esters and various preparations of the four raw materials of , ofloxacin and norfloxacin may cause harm to the breeding industry and human health or have potential risks. According to Article 69 of the "Regulations on the Administration of Veterinary Drugs", our Ministry has decided to stop the use of four veterinary drugs, lomefloxacin, pefloxacin, ofloxacin and norfloxacin in food animals, and revoke the relevant veterinary drug product approval documents. Number. The relevant matters are now announced as follows.

1. From the date of this announcement, except for products for non-food animals, the four raw materials of lomefloxacin, pefloxacin, ofloxacin and norfloxacin will no longer be accepted. Application for veterinary product approval number for various salts, esters and various preparations of the drug.

2. Starting from December 31, 2015, the production of various raw materials of lomefloxacin, pefloxacin, ofloxacin and norfloxacin for food animals will be stopped. For salts, esters and their various preparations, the veterinary drug product approval numbers of the relevant companies involved were revoked at the same time. Products produced before December 31, 2015, can be circulated and used before December 31, 2016.

3. Starting from December 31, 2016, we will stop operating and using the four APIs of lomefloxacin, pefloxacin, ofloxacin and norfloxacin for food animals. Various salts, esters and various preparations thereof.