Stemona has a certain anti-COVID-19 effect, will it be widely used in the future?

A news report said that scientists in China had discovered a specific anti-COVID-19 drug, and the news quickly reached the hot search list. Under the epidemic situation that the COVID-19 epidemic in COVID-19 is still spreading all over the world and China has been released in many places, if a specific drug for COVID-19 can be released, it will undoubtedly become another great artifact for everyone to resist COVID-19 infection.

What is this anti-COVID-19 drug that has aroused strong repercussions? Its name is cepharanthine, which is a single component extracted from traditional Chinese herbal medicines. The exclusive application by the elite team of authoritative experts in beijing university of chemical technology shows that cepharanthine with the concentration of 10 micromole/L can inhibit COVID-19 replication by 15393 times.

If you say that many friends still don't understand, you may have a better understanding. That is, if there are 15393 virus infections, the number of virus infections can be reduced to 1 under the action of 10μM cepharanthine. How strong is this effect? In a graduation thesis of Science magazine, it is emphasized that the antiviral drug data information of Stephania cepharantha is better than that of Redixivir and Paciclovir.

As a result, news like that is the scientific research achievement of biologists in China, which has certainly attracted your attention. Seeing that kind of information, I can't help but think of the short story of artemisinin. At the end of 1960s, China's elite scientific research team was ordered to tackle the key scientific and technological problems of finding special antimalarial drugs from traditional Chinese medicine. With the concerted efforts of several elite scientific research teams represented by experts and professors such as Tu Youyou, through unremitting efforts and hard work, several ancient recipes have been selected layer by layer, and the processing technology has been continuously improved. Finally, a special antimalarial drug artemisinin was discovered. In order to better determine the safety factor of drugs, more than a dozen biologists have been certified according to their own test methods when the toxicity and side effects of animal experiments are still unclear. Finally, through clinical research, it is found that artemisinin is a specific drug for treating plague.

Because of the appearance of artemisinin and the continuous development of its public health service level in China, in 20021year, China became the "dengue fever-free verification" of artemisinin. Artemisinin obtained from traditional Chinese medicine is still the first-line drug to resist the global dengue fever epidemic in COVID-19, and it still has irreplaceable enlightenment for the global eradication of dengue fever.

That is to say, Tu Youyou won the 20 15 Nobel Prize for his outstanding contribution to the acquisition of artemisinin. Tu Youyou said in his speech: Artemisinin is a gift from traditional Chinese medicine to people all over the world, and it is of vital practical significance to prevent cholera and other infectious diseases and safeguard the health of people all over the world.

Compared with artemisinin, can cepharanthine discovered this time become the second "artemisinin"? With the present research conclusion, everyone can naturally look forward to this matter. What is Stephania? What way does Stephania Stephania go from experimental link to clinical use? Everybody come and say.

Speaking of Stephania Stephania, there is actually no new extract. Stephania Stephania is a traditional Chinese herbal medicine, which is distributed all over China. It is a green plant of Stephania of Menispermaceae. Although the names of different areas are different, many basin friends should have seen this kind of green plant. In the basic theory of traditional Chinese medicine, Jin Buhuan is regarded as a kind of inferior medicine with the functions of clearing away heat, reducing swelling and diuresis and eliminating phlegm. However, contemporary Chinese medicine has found that Stephania Stephania contains a variety of components with physiological functions, and Stephania is one of the key components.

Not only has Stemona been fully studied scientifically, but also Chinese medicine preparations have been sold in Chinese mainland at this stage. This medicine is Stemona tablets. In terms of efficacy and function, it has the key function of clearing heat and cooling blood, and is used to treat leukopenia caused by radiotherapy and chemotherapy in tumor patients. However, it is also found that cepharanthine has uncertain anti-tumor effect in correlation analysis and specific medical applications. In a specific article published by the Cancer Treatment Center of the Third Hospital of Beijing Medical University on 20 12, it is emphasized that the application of Stephania alone can inhibit the proliferation of malignant tumor cells, improve human immunity and give full play to its anti-tumor effect, while the synergistic application of Stephania with radiotherapy and chemotherapy drugs can reduce the drug resistance of somatic cells, thus improving the curative effect of tumor chemotherapy. The specific mechanism may be that cepharanthine enhances the aggregation of anticancer drugs in somatic cells according to its effect on plasma membrane, and can also enhance the radiotherapy and chemotherapy of cancer cells.

From the analysis of anti-tumor effect of Jin Buhuan, we can also see the shadow of anti-COVID-19 effect of Jin Buhuan. Gold exchange can improve human immunity, improve the reliability of somatic cells, and then stimulate the body's cellular immunity to resist COVID-19 infection, plus its own anti-infection and anti-viral replication. It can be said that Stephania Stephania has the development potential to become a specific drug against COVID-19 from many fields.

At present, the patented invention of Stephania Stephania has been approved, and the research and development of related drugs has also been put on the agenda. Many friends will think that we need to take the specific medicine against COVID-19 immediately, or we can take cepharanthine tablets immediately to fight against COVID-19 infection. However, in view of this, we should advise everyone to be rational. After all, there is usually a long and bumpy road to go from research results to the real application of clinical medicine.

Compared with the whole process of artemisinin product development, the research and development of cepharanthine has many advantages. The research and development of artemisinin is from scratch, from the research of ancient books to the selection of suitable refining methods, to the determination of structure and further improvement of acquisition technology. And Stephania has many years of scientific research achievements, and at this stage, it has a complete acquisition production process and quality control methods. With the support of modern medical technology, there is no problem in obtaining a single ingredient. In view of the clinical application of cepharanthine against COVID-19, the following things may be done later.

First of all, on the basis of determining the anti-COVID-19 efficacy of somatic cells in vitro, it is necessary to establish an animal solid model of anti-COVID-19. The anti-COVID-19 activity and actual effect of the drug in animals were confirmed by anti-animal infection experiments. Artemisinin has been shown to be more than 99% efficient in experimental mouse models of dengue fever. Why didn't cepharanthine follow the ancestor's path and carry out the scientific research on premedical animal pharmacodynamics of COVID-19 animal infection model as soon as possible?

Secondly, pharmaceutical research experiments should be carried out step by step. What mode of administration can be chosen to better resist COVID-19 infection? Is it reasonable to take the tablets that have been introduced at this stage, or is there a faster route of administration? This requires in-depth analysis.

Thirdly, on the basis of animal experiments and scientific research on the preparation, quality, pharmacokinetics and reliability of traditional Chinese medicine, clinical research is also indispensable. On the one hand, clinical research needs to confirm the safety factor of drugs and understand the whole pharmacokinetic process of drugs in human body, and on the other hand, it needs to determine the anti-COVID-19 effect of drugs in specific allergic people, which is really suitable for everyone's attention. As a related ingredient in scientific research and clinical application for many years, the stability of this drug should be no problem, so we should pay special attention to it, or it is a matter of efficacy.

In this kind of scientific research work, we firmly believe that all researchers are doing it step by step, and some of the above problems are probably already being done or already being done. We also expect people to take out the China rate as soon as possible, make scientific research on the pharmacology and pharmacodynamics of Stephania Stephania's anti-COVID-19 drugs, and transform them into real anti-COVID-19 drugs as soon as possible, which can be used in clinical medicine.

In combination with the current regulations on drug control and application for registration, we firmly believe that it will take at least one to three years or even longer to carry out the above-mentioned scientific research and obtain the manufacturing and sales license. I wish all the researchers all the best, and let's hope that new drugs like that can be listed as soon as possible!