Why collagen injection can fill rhinoplasty and wrinkle removal?

The basic structure of collagen for injection is a supercoiled structure composed of three polypeptide chains. Each polypeptide chain has about 65,438+0,000 amino acids, and its molecular weight is about 65,438+0,000 daltons. The molecular weight of each collagen is about 300,000 daltons (the pore size of human body is 200).

These collagen molecules cross-link with each other to form a network structure, and form elastic connective tissue with elastin and polysaccharide, which can effectively resist the degradation of collagenase and provide mechanical functions such as support and protection, thus improving the elasticity and strength of skin.

Collagen, like hyaluronic acid, belongs to human tissue and has good biocompatibility, biodegradability and biological activity, such as low antigenicity, easy absorption in the body, promoting cell survival and growth, and promoting platelet coagulation. Collagen filling has been used in clinic for decades, so it has certain safety.

1. Extraction and classification of collagen

1. Collagen from animals: bovine collagen and porcine collagen.

Bovine collagen for Yimei injection is extracted from bovine dermis, and porcine collagen is extracted from pig. However, due to the different peptide chain structure of collagen from other animals, hypersensitivity may occur. According to statistics, about 3%~5% of patients are allergic to bovine collagen, and 70%~80% of them will have hypersensitivity reaction within 48~72 hours, so skin test is needed 4~6 weeks before use.

2. Autologous collagen: Collagen separated by centrifugal extraction from autologous fat and collagen produced by fibroblast culture.

The first is collagen extracted from autologous fat. Although this material is autologous and has no rejection, after injection, local inflammatory reaction may occur due to the activation of fibroblasts. The main disadvantage is that the duration of the effect is uncertain, because it is affected by any factors that may occur during the extraction process, resulting in a gap of 1 month to one year.

The other is to collect their own tissues and cultivate them. The process of culturing fibroblasts usually lasts for two months, and the time of injection treatment is 2~3 weeks. Therefore, the production cost is higher and the operation is more complicated, so it takes less time and there are fewer experienced doctors. However, some papers report that the effect of this method can last as long as seven years.

3. Allogeneic collagen: collagen extracted from dead fibroblasts and collagen extracted from fibroblasts donated in vivo.

Needless to say, this technology is not as good as the above two technologies, you just need to think about it carefully.

Second, certify products.

At present, there are many collagen egg fillers certified by FDA, including Zyderm and Zyplast of bovine collagen, Dermalogen of human collagen, Autologen of human collagen cultured in autologous skin, Cosmoderm of human collagen cultured in allogenic skin and Evolence of pig collagen.

At present, there are only two kinds of certification in China. One is SunMax from Taiwan Province Province, from SPF pig. There is also Fumeida in Jilin, which comes from bovine collagen.

"Figure/Shuangmei 1 Certification of Collagen Production in Taiwan Province Province"

"Photo/certification of skin Meida collagen produced in Changchun"

Third, advantages

1. Collagen is the main component of extracellular matrix, and it is an ideal biological scaffold, which can provide growth space for fibroblasts and a good medium for cell growth. After injection into the concave part of human body, it can not only occupy the space, but also induce host cells and capillaries to migrate into the injected collagen. Host fibroblasts can carry out normal cell activities and synthesize their own collagen and other extracellular matrix components when oxygen and nutrients are transported by capillaries. So just after injecting collagen, I often feel hard. After injection of 1~2 weeks, collagen and collagen began to fuse, gradually absorbed and felt more and more natural. 1~2 months later, it presents a more real and natural feel than other types of fillers, which is also a major advantage of collagen injection filling.

2. Collagen under the standard of cosmetic injection can be completely absorbed and degraded by skin tissue.

3. If the water absorption of collagen is higher than that of hyaluronic acid, it is not easy for hyaluronic acid to have strong water absorption when filling.

4, it has hemostatic effect and is not easy to spread to the distance, so it is less likely to cause embolism than hyaluronic acid and autologous fat.

5. Repeated injection of collagen can stimulate dermal fibroblasts to produce new collagen and form new tissues, which has the function of repair and regeneration.

Fourth, shortcomings.

1, collagen is absorbed quickly, and the retention time in the tissue is only 3~6 months, which leads to linear degradation, continuous volume reduction, excessive injection and short cycle of satisfactory optimal morphology.

2. Collagen is species-specific and tissue-specific, which may cause allergic reactions to people with certain constitutions, so it is best to have a skin test before use.

3. There may be hidden dangers of animal-derived pathogens, such as wind disease.

4. Collagen must be stored in cold storage, which is inconvenient to transport.

Verb (abbreviation for verb) complications

Due to the rapid absorption of collagen, the common adverse reactions such as excessive injection, uneven injection, induration and unsatisfactory effect are not too big problems, so serious complications are rare.

However, allergy needs attention, and it is also a complication different from hyaluronic acid, which is the most common. Moreover, the products injected into the human body by surgery are difficult to clean, and they are not dissolved by lysozyme like hyaluronic acid. Because collagen is fused between cells, it can only be controlled by continuous treatment of antiallergic drugs, so skin test is extremely important.

Text: Zhou Xiaoxiao | Talking about the official account operation of WeChat for cosmetic surgery.

Some pictures are collected from the Internet, and the articles are original. Reprinting is prohibited.

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