Would like to ask that kind of medicine for treating hepatitis B is easy to use? What about information and investment?

What are the effective drugs for treating hepatitis B at present?

What are the effective anti-HBV drugs at present? How to choose medication?

New progress in the treatment of chronic hepatitis B

1. therapeutic goal: to prevent the development of liver disease by inhibiting the replication of hepatitis b virus or eliminating infection, specifically: ① serum HBVDNA is negative; ② Serum HBeAg was negative and anti-HBe was positive (that is, "Big Three Yang" changed to "Small Three Yang"); ③ Serum ALT is normal; ④ Histological improvement of liver.

2. Indications of antiviral therapy: the serum HBVDNA or/and HBeAg positive lasted for more than 6 months; Serum ALT level increased repeatedly; Histological examination of liver showed chronic infection of hepatitis B virus with moderate inflammation.

3. Effective anti-hepatitis B virus drugs:

3. 1a- interferon:

1992, the US Food and Drug Administration (FDA) approved the application of interferon A to treat patients with chronic hepatitis B, which has the functions of inhibiting virus replication and enhancing immunity. The recommended dosage is 5 million units per subcutaneous injection, three times a week, and the course of treatment is at least 6 months. At present, these drugs are imported drugs such as interferon, roxithromycin, and Huifuren, as well as domestic drugs such as siroquine, Vanderbilt, Andafen and Intveen.

The indicators with better curative effect include: before treatment, the serum HBVDNA level is lower than 200pg/mL, the serum ALT is higher than 100U/L, the liver histological examination shows obvious inflammatory activity, female, with a history of acute hepatitis, short duration of virus infection, non-mother-to-child transmission and non-virus variation.

Possible adverse reactions include: cold-like symptoms, bone marrow suppression (manifested by decreased peripheral blood white blood cell count and platelet count), loss of appetite, emaciation, alopecia, depression and so on.

3.2 Lamivudine:

Lamivudine (China's trade name is "Hepudine") is another drug for treating hepatitis B virus approved by FDA in February 1998. It only inhibits virus replication. The recommended treatment plan is to take 100mg orally every time,/kloc-0 once a day, and the course of treatment is at least 1 year.

Possible adverse reactions: No obvious adverse reactions have been found so far.

Note: After 9 months of treatment, it is necessary to check the virus mutation to prevent drug resistance.

3.3 famciclovir:

Famciclovir (trade name "Li Zhufeng") is another nucleoside analogue, and its mechanism of action is similar to lamivudine. The recommended scheme is to take 0.5g orally each time, three times a day, and the course of treatment is at least 4 months.

3.4 immunomodulator:

Thymosin a 1 (trade name "Ridaxian") is an immune enhancer, which plays an antiviral role by enhancing its own immunity to hepatitis B virus. Usually used in combination with interferon-a or lamivudine. The recommended scheme is subcutaneous injection of 1.6mg each time, daily 1 time, twice a week for four consecutive days, and the course of treatment is 4-6 months.

4. Precautions: Monitor serum ALT, HBVDNA, HBeAg/ anti-HBe during the treatment, and treat under the guidance of professional doctors.