What is Symptomatic Dry Eye in Major Syndrome?

Some symptoms of Major syndrome include dry eyes, astringent eyes, foreign body sensation in the eyes, blinking, photophobia, etc., which can easily be misdiagnosed as dry eye syndrome. Dry eye syndrome mainly manifests as dry eyes with a desire to cry but no tears. Moreover, long-term dry eyes are often complicated by ocular congestion, conjunctivitis, corneal epithelial rupture and the adhesion of filaments. Long-term damage can cause corneal and conjunctival lesions. , and will affect vision.

Meige syndrome is a group of extrapyramidal disorders first described by French neurologist Henry Meige. The main manifestations are blepharospasm of both eyes, oromandibular dystonia, and facial dystonia-like involuntary movements. Henry Meige first reported Meige syndrome in 1910. Since then, it has been called Brueghel syndrome, blepharospasm, oromandibular dystonia, etc. Symptoms of Major syndrome? Tell us about it

Symptoms of Major syndrome?

Major syndrome usually starts in old age, mostly between 40 and 70 years old, and is more common in women. , the male:female ratio is 1:2-3. It usually starts slowly. Before the onset, there will be irritation or discomfort in one or both eyes, shyness, increased blinking frequency, and dry eyes. Later, it will develop into blepharospasm. Symptoms worsen when fatigue, sunlight stimulation, gaze, and tension occur, decrease when the mind is focused on other things other than blepharospasm, and disappear during sleep.

The first symptom of most patients is paroxysmal blepharospasm. The main symptom of blepharospasm is the contraction of the orbicularis oculi muscle, and the contraction of the forehead and nose muscles centered between the eyebrows, which is manifested by an increase in the number of blinks. , tears, and a few develop functional blindness over 1-2 years, eventually developing into severe blepharospasm, difficulty opening eyes, and even losing the ability to take care of themselves. Some patients start with blepharospasm and gradually progress to the lower face, showing symmetrical, irregular and hyperactive contraction of the oral and mandibular muscles. Tension of the mandibular muscles can prevent chewing, swallowing and speaking. When laryngeal muscles and respiratory muscles are violated, spasmodic dysphonia and dysphonia may occur. Difficulty breathing.

Eyelid involvement: In mild cases, it may manifest as eye discomfort, dry eyes, photophobia, and increased blinking, and some may be misdiagnosed as "conjunctivitis"; in slightly more severe cases, episodic eye closure and difficulty in opening the eyes may occur. , you need to use your fingers to open the eyelids; in severe cases, it can cause functional blindness. Oro-mandibular involvement: Manifested as involuntary mouth opening, mouth closing, pursed lips, lip retraction, cheek biting, tongue biting, and teeth grinding.

Notes

A large number of literature reports that botulinum toxin (BTX) is effective for this disease, but it is expensive and has side effects, which limits its use. Symptomatic dry eye is the most common, along with dysphagia, ptosis, dyspnea, photophobia, diplopia, etc.