Introduction of contraindications to drugs

Miss Chen recently traveled and had a toothache, so she brought a box of metronidazole. I played outside and visited many restaurants when I was in the mood. One day after dinner, Miss Chen slept until midnight, and suddenly felt dizzy, nauseous and went into shock after vomiting. Only by being sent to the hospital in time can he save his life. The doctor told him that metronidazole would lead to the accumulation of alcohol in the body, interfere with the oxidation process of alcohol and lead to the above-mentioned series of reactions.

Both Chinese and western medicine have dietary taboos.

Grapefruit juice: avoid drinking grapefruit juice and eating foods with high salt content during taking antihypertensive drugs and anti-angina drugs. Because naringin in grapefruit juice can affect the action of some enzymes in the liver, and these enzymes are related to the metabolism of antihypertensive and antianginal drugs. Taking felodipine as an example, a glass of grapefruit juice can increase the blood drug concentration in the body by 134%, which is equivalent to taking more than twice the drug, which is obviously excessive and greatly increases the side effects.

Alcohol: Avoid drinking alcohol when taking headache medicine. Because alcohol needs to be converted into acetaldehyde after entering the human body, and then further converted into acetic acid for metabolism. Drugs for headache can prevent acetaldehyde from oxidizing into acetic acid, which leads to the accumulation of acetaldehyde in the body and aggravates headache symptoms.

Tea: Take calcium supplements and avoid spinach, tea and almonds rich in oxalic acid. Because oxalic acid will combine with calcium in the small intestine, it will produce insoluble substances that cannot be absorbed, which will hinder the absorption of calcium and may also form stones.

What medicines can't be taken with tea?

Tea does greatly reduce the effect of some drugs. Remember four kinds of drugs that will fail when you meet tea:

1. Nourishing Chinese medicine

Saponins and alkaloids contained in the tonic will combine with tea polyphenols to produce precipitates that cannot be absorbed by the human body, thus reducing the nourishing effect of the tonic. Commonly used tonics, such as ginseng, astragalus, Polygonum Multiflori Radix, Radix Rehmanniae Preparata, etc. , all contain more active substances such as alkaloids. Therefore, when taking tonic, it is not advisable to drink tea at the same time, let alone take tonic with tea instead of water.

2. Drugs containing metal ions

Tea polyphenols, also known as tea tannins, are easily decomposed into tannins in the body. Tannic acid can form water-insoluble tannic acid compounds with metal ions in drugs, such as iron tannic acid and iron agent for treating anemia, and aluminum tannic acid and aluminum hydroxide for treating ulcers.

3. Sedatives

The alkaloids in tea are mainly purine alkaloids, the most of which is caffeine, and the rest are theobromine and theophylline. Caffeine and theophylline can excite the central nervous system and reduce the sedative effects of benzodiazepines and barbiturates such as diazepam and estazolam.

4. Alkaloids

Tea polyphenols in tea account for about 20%-25% of dry weight. Tea polyphenols will react with alkaloids such as berberine, ephedrine and scopolamine to form insoluble organic base precipitate, which will affect the absorption of these drugs in the body. Common drugs are berberine, ephedrine and belladonna tablets.

In addition to the above categories of drugs, there are some drugs that will fail when they encounter tea, such as enzyme preparations (such as multi-enzyme tablets), dipyridamole (dipyridamole) and so on. Generally speaking, except for some special drugs that need to be taken as an introduction, such as wine, it is better to take other drugs with boiling water. It is not recommended to bring drinks, juice, etc. , especially tea. In addition, try to avoid drinking tea within 2-3 hours before and after taking the medicine.

Beware of milk, juice, drugs and death.

Milk, fruit juice, cola and other beverages will interact with drugs, affecting the curative effect and causing death.

For example, taking antipyretic and analgesic drugs such as compound aspirin and sugar-coated antibiotics such as berberine and acetylspiramycin together with fruit juice or acidic drinks will accelerate drug dissolution, damage gastric mucosa and even lead to gastric mucosal bleeding; Taking alkaline stomachache drugs such as aluminum hydroxide will neutralize acid and alkali and make the drugs completely ineffective; Taking sulfanilamide drugs such as compound sulfamethoxazole will reduce the solubility of the drugs and easily cause urinary calculi; If you take tea to treat anemia, the tannic acid in tea will combine with iron and weaken the curative effect. The general method of taking medicine is to take it with warm water, but the practice of taking tablets with hot water may greatly reduce the efficacy of some drugs.