Thyroid hormone, thyrotropin and thyrotropin-releasing hormone, their respective functions, what is the relationship between them? Ask the great god to explain!

Thyroid hormone is an amino acid derivative, which can promote metabolism and development and improve the excitability of nervous system. Breathing, rapid heartbeat and increased thermogenesis. Secreted when cold and nervous.

When people are in danger and nervous state, they will first stimulate the hypothalamus to release thyrotropin-releasing hormone. The increase of this hormone concentration in blood will act on the pituitary gland, prompting it to release thyrotropin, that is, increasing the content of thyrotropin in blood, and thyrotropin will further act on the thyroid gland, increasing the secretion of its gland cells, that is, secreting a large amount of thyroid hormone. (generally, it does not directly raise blood sugar. )

Growth and growth hormone play a synergistic role; Thermoregulation works synergistically with adrenaline.

Thyroid stimulating hormone (TSH) is a hormone secreted by pituitary gland to promote thyroid growth and function. Human TSH is a glycoprotein, containing 2 1 1 amino acids, and sugar accounts for about 15% of the whole molecule. The whole molecule consists of two peptide chains-α chain and β chain. TSH promotes thyroid function in an all-round way. Promote the release of thyroid hormone in the early stage, and promote the synthesis of T4 and T3 in the later stage, including strengthening iodine pump activity, enhancing peroxidase activity, promoting thyroglobulin synthesis and tyrosine iodination.

Thyrotropin-releasing hormone acts on thyrotropin cells of adenohypophysis, binds to receptors on cell membrane, activates adenylate cyclase -cAMP- protein kinase system, enables thyrotropin cells to synthesize and release thyrotropin, and maintains its normal secretion. TRH can also stimulate the pituitary gland to secrete prolactin (PRL). Because people's needs (such as excitement) or the needs of individual physiological functions will stimulate the hypothalamus,

Thyroid stimulating hormone releasing hormone is produced by hypothalamus (hypothalamus: visceral function control center).

Thyrotropin-releasing hormone diffuses to the pituitary gland, prompting the pituitary gland to secrete thyrotropin (thyrotropin: promoting the growth and development of thyroid gland, regulating the synthesis and secretion of thyroid hormone, etc. ).

When the content of thyroid hormone in blood is too high, it will inhibit the hypothalamus from secreting thyrotropin-releasing hormone, which is called feedback regulation.

[Thyroid hormone (T4 or T3) is an amino acid derivative containing iodine, thyrotropin (TSH) is a glycoprotein, and thyrotropin-releasing hormone is a neurohormone. ]