Efficacy of Trichosanthes kirilowii Medicinal Value of Trichosanthes kirilowii

Trichosanthes kirilowii has antipyretic, thirst-quenching, diuretic, antitussive and expectorant effects. Seeds contain fat, flower fat and oil; Fruit contains triterpenoid saponins, organic acids, resins, sugars and pigments. The root contains protein, saponin and acid. Then introduce the efficacy and medicinal value of Trichosanthes kirilowii.

Function of Trichosanthes kirilowii

Antibacterial and anticancer effects. Trichosanthes kirilowii has certain inhibitory effect on Escherichia coli, Shigella sonnei and Proteus in vitro. The water extract (1: 2) also has inhibitory effect on some skin fungi in vitro. In vitro, Trichosanthes kirilowii decoction (20% decoction) has lethal effect on ascites cancer cells. Some people think that Trichosanthes kirilowii bark and Trichosanthes kirilowii kernel are both effective, but the former is better. Seed shells and fatty oils are invalid. Alcohol and ether extracts are also effective. 60% ethanol extract has the best effect in vitro. But in animal experiments, its effect is not significant and unstable; In vivo, the effect on sarcoma is stronger than that on ascites cancer cells.

Expectorant action

Animal experiments show that the total amino acids separated from melon peel have good expectorant effect.

diarrhea

Melon baskets contain laxative substances and have a laxative effect. The role of Trichosanthes kirilowii is weak; Benevolence has a strong role; Trichosanthes kirilowii ointment is used to relieve.

Effects on cardiovascular system

Trichosanthes kirilowii peel (35%) decoction and alcohol precipitation (65%) concentrated solution and Trichosanthes kirilowii extract injection (hereinafter referred to as Trichosanthes kirilowii injection) have the effect of dilating coronary artery of isolated guinea pig heart, and the latter is more significant. When the content of crude drugs per 1 ml perfusion solution is 2.5 or 50 mg, the coronary flow can be increased by 55% or 7 1% respectively. Similar results were obtained in the isolated heart-free test. Trichosanthes kirilowii injection has obvious protective effect on acute myocardial ischemia induced by pituitrin in rats. It can obviously improve the tolerance of mice to normal pressure and low pressure hypoxia; The mice injected with isoproterenol in advance can also improve the survival rate under hypobaric hypoxia, but it does not prolong the sleep time of secobarbital sodium in mice, suggesting that its effect of improving hypoxia tolerance has nothing to do with the central nervous system. The crown expansion strength of different parts of Trichosanthes kirilowii is: Trichosanthes kirilowii bark >; Fructus Trichosanthis ointment > Fructus Trichosanthis > Fructus Trichosanthis shell.

Antibiotic action

1:5- 1: 1 Trichosanthes kirilowii decoction or infusion has inhibitory effect on gram-negative bacteria such as Escherichia coli in vitro; It also has a certain inhibitory effect on staphylococcus, pneumococcus, hemolytic streptococcus A, influenza, tinea cruris and Nocardia stellata.

Anticancer effect

1:5 Gualou decoction can kill ascites cancer cells in mice in vitro (slide method). The anti-cancer effect of Trichosanthes kirilowii bark in vitro is better than that of Trichosanthes kirilowii kernel, and the 60% ethanol extract has the strongest effect. The white amorphous powder obtained from the ether extract of Trichosanthes kirilowii also has anticancer effect in vitro. Animal experiments show that Trichosanthes kirilowii has a certain inhibitory effect on sarcoma. The effect on ascites carcinoma is not obvious. It has also been reported that Trichosanthes kirilowii preparation is ineffective on U- 14 and S- 180 transplanted in mice.

Anti-ulcer effect

Broussonetia papyrifera fruit was extracted with 50% ethanol at 90℃ for three times, and then dried in vacuum to obtain a dark brown powder (TKE). In the experiment of pyloric ligation in rats, TKE500 and TKE 1000mg/kg significantly decreased the secretion and concentration of gastric acid in rats, while TKE 100mg/lgTKE increased the above indexes. 100,500 and 1000mg/kgTKE have inhibitory effects on the ulcer caused by pyloric ligation, and the inhibitory rates are 44.4%, 68.2% and 84. 1% respectively. The same dose of TKE reduced the gastric injury induced by water immersion in rats by 65438 06.5%, 565438 0% and 66.9% respectively. Although the gastric mucosal damage caused by histamine has been alleviated, the difference is not significant. TKE at 500mg/kg and 1000mg/kg had protective effects on gastric mucosal injury induced by 5- hydroxytryptamine, and the inhibition rates were 59. 1% and 63.6% respectively. The inhibitory rates of TKE (500, 1000 mg/kg) on gastric mucosal injury induced by ethanol hydrochloride were 80.9% and 94.8%, respectively. Some necrosis agents, such as 1ml0.6molHCI and 0.2molNaOH or 35%NaCl, can cause severe gastric mucosal damage, and TKE can alleviate this damage in advance. In addition, TKE can also treat gastric ulcer caused by acetic acid. In vitro experiments, 2.5× 10(-3)g/kg and1.0×10 (-2) g/kg tke have obvious relaxing effects on the ileum contraction induced by acetylcholine in mice. It shows that higher dose of TKE can inhibit gastric acid secretion and resist ulcer, and TKE can alleviate the ulcer caused by acetic acid, which shows that TKE may have the effect of treating chronic ulcer.

Anti-aging effect

The effect of 2.5% ethanol extract of Trichosanthes kirilowii acid on the fecundity of Drosophila melanogaster was observed. From 10 to 15, the number of Drosophila melanogaster in control group was 65.813.0, and that in Trichosanthes root group was130.212.6.