Urgently ask about the symptoms of leukemia

1. The onset of leukemia is sudden or slow, and many children and adolescents suffer from sudden illness. Common initial symptoms include: fever, progressive anemia, obvious bleeding tendency or joint pain. Most of the patients with slow onset are elderly and some young patients, and their condition is gradually progressing. Most of these patients have progressive fatigue and weakness, pale face, palpitation and shortness of breath after fatigue, loss of appetite, weight loss or fever for unknown reasons as the first symptoms. In addition, a few patients can have convulsions, blindness, toothache, swollen gums, pericardial effusion and paraplegia of both lower limbs as the first symptoms.

2. Fever and infection

A. Fever is one of the most common symptoms of leukemia, which can occur in different stages of relapse and have different degrees of fever and heat type. The main cause of fever is infection, among which angina, stomatitis and perianal inflammation are the most common, and pneumonia, tonsillitis, gingivitis and perianal abscess are also common. Ear inflammation, enteritis, carbuncle, pyelonephritis, etc. can also be seen, and sepsis and sepsis can also occur in severe infections.

B. Bacteria are the most common pathogens, and Gram-positive cocci are the main pathogens in the early stage of the disease. Although virus infection is rare, it is often dangerous. Cytomegalovirus, measles or varicella virus infection is prone to pneumonia, so we should pay attention to it.

C. Hemorrhage is also a common symptom of leukemia. The bleeding site can be all over the body, with skin, gums and nasal cavity bleeding being the most common, and there may also be hemorrhage in retina, ear, intracranial, digestive tract, respiratory tract and other internal organs. Menstruation in women is also common and can be the first symptom.

D, anemia can appear in the early stage, and a few cases can appear refractory anemia months or years before diagnosis, and then develop into leukemia. Patients are often accompanied by fatigue, pallor, palpitation, shortness of breath, edema of lower limbs and other symptoms. Anemia can be seen in various types of leukemia, but it is more common in elderly patients, and many patients often take anemia as the first symptom.

Symptoms of chronic myeloid leukemia:

The onset is slow, and there are often no conscious symptoms in the early stage. Patients can feel no discomfort for a long time, and most of them are diagnosed because of abnormal hemogram or splenomegaly when they seek medical treatment for other diseases.

with the development of the disease, there may be symptoms of hypermetabolism such as fatigue, low fever, hyperhidrosis or night sweats, weight loss, etc. Due to splenomegaly, the left upper abdomen feels bloated and full after eating.

The patient's complexion, nail bed and lips are pale, and the most prominent is splenomegaly, which often reaches the umbilical plane when he goes to the hospital. There is often tenderness in the lower part of the sternum. Bleeding spots can appear in the skin and mucosa of patients with advanced stage. Painless masses can appear in tissues such as orbit, head and breast.

The disease can be stable for 1-4 years, and then it will enter an accelerated period, and anemia and more symptoms will appear quickly. After that, it turned into acute myeloid leukemia.

Ten Symptoms of Leukemia

● Sudden onset Leukemia has a sudden onset and a short course, especially in children and young people.

● The first symptom of fever acute leukemia is mostly fever, which can be manifested as relaxation fever, missed fever, intermittent fever or irregular fever, and the body temperature is 37.5 ~ 4℃ or higher. Sometimes I feel cold, but I don't feel chills.

● Hemorrhage is a common symptom of leukemia. The bleeding site can be found all over the body, especially in nasal cavity, mouth, gums, subcutaneous and fundus, and there can also be intracranial, inner ear and visceral bleeding.

● Anemia can occur in the early stage, which is characterized by pale face, dizziness and palpitation.

● hepatosplenomegaly occurs in 5% leukemia patients, especially in acute lymphoblastic leukemia.

● Lymph nodes are extensive lymphadenopathy, especially acute lymphoblastic leukemia, but acute lymphoblastic leukemia is not as obvious as chronic lymphocytic leukemia. Superficial lymph nodes are in the neck, submaxillary, groin and so on, while deep lymph nodes are near mediastinum and viscera. The swollen lymph nodes are generally soft or moderately hard, and the surface is smooth without tenderness and adhesion.

● Skin lesions and mucosal lesions with leukemia are characterized by nodules, lumps and maculopapules. Mucosal injury is characterized by swelling and ulcers in nasal mucosa, respiratory mucosa and oral mucosa.

● White blood cell infiltration can occur in the arachnoid membrane and meninges of nervous system inflammation, which is similar to brain tumor and meningitis, and patients will have symptoms such as increased intracranial pressure, meningeal irritation and limb paralysis.

● After the pathological changes of bones and joints infiltrate into bones and joints, bone and joint pain often occurs, which is manifested as dull pain, soreness and occasional severe pain in sternum, humerus, shoulders, elbows, hips and knees. Children with acute lymphoblastic leukemia often have tenderness of bones and joints.

● Other leukemia cells can infiltrate the respiratory, digestive and genitourinary systems, as well as the orbit, lacrimal gland and fundus, etc. Patients may have diffuse or nodular changes in the lungs, accompanied by pleural effusion, digestive dysfunction, proteinuria, hematuria, amenorrhea or menorrhagia, exophthalmos and reduced vision.