Tell me about people who eat cephalosporins but can't drink.

Disulfiram-like reaction may occur after drinking cephalosporin. This will lead to blushing, increased heart rate, low blood pressure and other manifestations. In severe cases, it can cause respiratory depression, myocardial infarction, acute heart failure, convulsion and death.

Disulfiram-like reaction can be explained by normal alcohol metabolism. After alcohol enters the human body, it is first converted into acetaldehyde by alcohol dehydrogenase in the liver, then converted into acetic acid by acetaldehyde dehydrogenase, and acetic acid enters the citric acid cycle, and finally converted into water and carbon dioxide.

These two enzymes play an important role in alcohol metabolism. However, the methylthiotetrazole group (MTT) contained in cephalosporins, especially the third-generation cephalosporins, will inhibit the activity of acetaldehyde dehydrogenase, making acetaldehyde unable to degrade, causing acetaldehyde poisoning, which is the so-called disulfiram-like reaction.

Extended data

Cephalosporin is the general term for cephalosporins. Cephalosporin is a kind of antibiotics obtained by semi-synthetic modification of the side chain of natural cephalosporin C cultured from Cephalosporium coronatum.

There are about 30 kinds in common use, which can be divided into the first generation, the second generation, the third generation and the fourth generation according to the different invention time and antibacterial performance. Never use it before or after drinking. It is prone to shock and syncope, and the elderly may even be life-threatening. Cephalosporins occupy a large share in the antibiotic market, and their related intermediates also show considerable market potential.

Ceftriaxone sodium, cefazolin sodium, cefotaxime, ceftriaxone, cefoperazone and cefuroxime (ester) are the most popular cephalosporins, and the corresponding intermediates include 7-ACA, 7-ADCA, GCLE, aminoximic acid, AE- active ester, triazine ring, tetrazole acetic acid, methimazole tetrazole and HO-EPCP.