I caught a cold, and my friend joked that I should be careful of the flu. I remember amantadine's cold medicine can resist viruses. Is it really antiviral? What is the principle?

Mainly used for: 1. Prevention and early treatment of influenza A in Asia. Combined with antibiotics, it can treat septicemia and viral pneumonia and has antipyretic effect. 2. Anti-paralysis. Swchwab et al. found that amantadine can prevent the symptoms of paralysis agitans after influenza, and introduced this drug to treat nervous system diseases. It can obviously inhibit the virus from shelling, which may affect the cell and lysosomal membrane, make the virus nucleic acid unable to shell, and also prevent the virus from infiltrating into the cell and interfering with the early replication of the virus. As for the mechanism of anti-tremor paralysis, some people think that it acts on the central dopaminergic system, but others think that it has nothing to do with the dopaminergic system. Its mechanism is as follows: 1. Increase dopamine synthesis. 2. Promote the release of dopamine. 3. Mechanism of inhibiting dopamine active uptake. 4. Direct stimulation of dopaminergic receptors. In animal experiments, Stone( 1976) observed the reaction of dopamine and amantadine in cerebral cortex and caudate nucleus by microelectrophoresis. It was found that both drugs could inhibit the discharge of single cells, and the discharge reaction could be antagonized by chloropropene, a dopamine receptor blocker, while amantadine could not enhance the effect of dopamine. Therefore, amantadine can not inhibit monoamine uptake. In addition, it was found that the response of monoamine-deficient animals to dopamine was not different from that of the control group, but the response to amantadine decreased, but it did not disappear, indicating that amantadine partially released catecholamine, and the other effects were due to its direct stimulation of postsynaptic receptors.

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