How to treat hepatitis C

Disease analysis: The treatment goal of hepatitis C is to eliminate hepatitis C virus and get cured. Eliminate or alleviate hepatitis C virus-related liver injury and extrahepatic manifestations, reverse liver fibrosis, prevent progression to cirrhosis, decompensated cirrhosis, liver failure or hepatocellular carcinoma, improve the long-term survival rate of patients, improve the quality of life of patients, and prevent the spread of hepatitis C virus.

First, general treatment.

1, acute hepatitis C: generally self-limited, mostly fully recovered, mainly with general treatment and symptomatic support treatment. Isolation should be carried out in the acute phase, and those with obvious symptoms and jaundice should stay in bed. During the recovery period, the activity can be gradually increased, but overwork should be avoided. Diet should be light and easy to digest, and vitamins should be supplemented appropriately. Those with insufficient calories should be supplemented with glucose intravenously to avoid drinking alcohol and using drugs that damage the liver. With drugs to treat symptoms and restore liver function, drugs should not be too much, so as not to increase the burden on the liver.

2. Chronic hepatitis C: those with obvious symptoms or serious illness should emphasize bed rest, and those with mild illness should take fatigue after activities as the degree. Proper consumption of digestible food with high protein, high calorie and high vitamins is beneficial to liver repair, prevention of fatty liver and avoidance of drinking, so it is unnecessary to overemphasize high nutrition. Make patients have a correct view of the disease and have patience and confidence in the treatment of hepatitis.

Second, medication.

1, antiviral therapy: generally, as long as hepatitis C virus is positive, antiviral therapy is needed. The purpose is to inhibit virus replication for a long time, reduce infectivity, improve liver function, alleviate liver tissue lesions, improve quality of life, reduce or delay the occurrence of cirrhosis, liver failure and hepatocellular carcinoma, prolong the survival period, and pursue clinical cure for some suitable patients. Antiviral drugs include interferon-α, sophorbuvir, patavir and gekarivevir.

2, improve and restore liver function:

(1) Nonspecific hepatoprotective drugs: vitamins, reduced glutathione, glucurolactone, etc.

(2) Enzyme-lowering drugs: Schisandra chinensis (biphenyl diester), Sophora Tonkinensis (matrine), licorice extract, bicyclol and other weeds with enzyme-lowering effects.

(3) Yellowing drugs: Salvia Miltiorrhiza, Yinzhihuang, potassium magnesium aspartate, prostaglandin E 1, adenosylmethionine, low molecular dextran, phenobarbital, anisodamine, corticosteroids, etc. Glucocorticoid is used with caution, with mild symptoms and severe liver cholestasis. Other anti-jaundice drugs are ineffective and there are no contraindications.

3. Immunoregulation: such as thymosin or thymopeptide, transfer factor, specific immune RNA, etc. Some Chinese herbal medicine extracts such as lentinan and Coriolus versicolor polysaccharide also have immunomodulatory effects.

4. Anti-hepatic fibrosis: If there is evidence of hepatic fibrosis, anti-hepatic fibrosis treatment can be used. There are mainly salvia miltiorrhiza, Cordyceps sinensis, nucleolus extract and so on. The anti-fibrosis effect of Salvia Miltiorrhiza can increase the activity of collagenase in liver and inhibit the synthesis of collagen ⅰ, ⅲ and ⅳ.

Third, surgical treatment.

If hepatitis C develops into cirrhosis and the condition is serious, liver transplantation can be performed.

Fourth, other treatments.

If liver failure occurs, artificial liver support system can be used for treatment.