How to quickly lock the target and attack in World of Warcraft?

Create a macro or set focus.

If you write a macro

/target target name

/cast skill name (level X)

you can cast it directly on that target Use skills

If you want to attack directly, just

/target target name

/attack

will do

If you select the target and then cast skills and then stop attacking, such as those kicked by thieves

/Target target name

/cast kick

/stopattack

Stop attacking after casting the skill