What is the special significance of vaccination with nine-valent HPV vaccine?

There is no special meaning. The nine-valent vaccine is used to prevent cervical cancer caused by human papillomavirus (HPV) infection, which can prevent more than 90% of cervical cancer. 2065438+On April 28th, 2008, SFDA conditionally approved a nine-valent HPV vaccine for cervical cancer to be marketed in China. Vaccination is primary prevention and screening is secondary prevention, both of which are equally important. Therefore, cervical cancer screening measures should not be relaxed because of vaccination.

The 9-valent HPV vaccine has good immunogenicity, and the positive rate of related serum antibodies can reach nearly 100% after three doses of inoculation. One month after the vaccination plan was completed, the maximum geometric average titer of antibody was 100 times higher than that after natural infection.

In the next two months, the value dropped to 10 times and remained stable. The antibody level produced by this vaccine can last for at least four years. In the clinical trial of the effectiveness of the 9-valent HPV vaccine, the main end points observed are the persistent infection of related human papillomavirus type, genital warts of related human papillomavirus type, cervical intraepithelial neoplasia and external genital or vaginal intraepithelial neoplasia.

Limitations:

Because the cervical cancer vaccine developed and sold can not cover all high-risk types, the nine-valent human papillomavirus vaccine can not protect all diseases caused by related tumors or high/low-risk types; Therefore, in the specification of the 9-valent HPV vaccine approved by the FDA of the United States, the following 9 restrictions have been determined:

1. Vaccination will not cancel/terminate women's long-term cervical cancer screening (secondary prevention).

2. Vaccination will not cancel/terminate the recommended screening in anal cancer.

3. Vaccine can't protect people who have been infected with human papillomavirus.

4. In addition to the corresponding disease types, vaccines cannot prevent related diseases.

5. The vaccine does not treat diseases caused by the position-related types described in the instruction.

6. Except for the corresponding type of human papillomavirus, the vaccine has not been shown to prevent vulva, vagina and anal cancer caused by human papillomavirus.

7. The vaccine cannot prevent diseases caused by non-human papillomavirus.

This vaccine can't protect all people who have been vaccinated.

9. The protective effect of this vaccine on CIN (++) in people over 26 years old has not been confirmed.

Refer to the above content: Baidu Encyclopedia-Nine-valent HPV Vaccine