What disease is variant vasculitis, how to cause it and how to treat it?

Allergic vasculitis is a common disease, and its histopathological features are vasculitis with leukorrhagia, skin injury and multiple visceral injuries. This disease has many names. In order to prevent confusion, Ruiter thinks it is more appropriate to call this disease allergic vasculitis, which reflects the inflammatory changes of blood vessels caused by allergic reactions. The severity of this disease varies from skin lesions that can be cured in a few weeks to multiple organ damage, and even life-threatening in severe cases.

diagnose

The main manifestations of the disease are erythema nodules on the lower limbs, accompanied by tenderness, and may also be accompanied by purpura, purpura papules, wheal, mound blisters and other skin lesions. Skin histopathology showed inflammatory cell infiltration in the blood vessel wall, mainly polynuclear leukocytes and fibrin deposition, polynuclear leukocytes infiltration around the blood vessel, accompanied by nuclear dust and erythrocyte exudation. According to the above characteristics, the diagnosis can be confirmed.

Treatment measures

Active treatment can be carried out according to different causes and symptoms.

1. Because of fatigue, myalgia, joint pain, and swelling of patients' lower limbs, they need to rest. Severe patients should stay in bed and improve the affected limb to reduce the influence of venous water pressure on the lesion.

2. Remove the cause to reduce the source of antigen and drive away the infected focus, such as virus and bacterial infection. The influence of stopping allergic drugs and foreign proteins.

3. If you have upper respiratory tract infection, you can treat it with antibiotics. Double-effect penicillin 80× 104U intramuscular injection, 1 ~ 2 times a day. Or erythromycin 0.25g, 4 times a day, orally; Or cephalosporin.

4. In order to prevent antibody production, reduce the formation of immune complex, and alleviate inflammatory reaction, oral prednisone 20 ~ 40 mg is given in several times.

5. Colchicine 0.5mg twice a day can inhibit leukocyte chemokines, inflammation and stabilize lysosomal enzymes.

6. Indomethacin 25 mg, three times a day, may inhibit the synthesis of prostaglandin.

7. Aspirin 0.3g plus dipyridamole 25mg three times a day can inhibit platelet aggregation.