What drugs have good effects and small side effects in treating depression?

I think SSRI drugs with less side effects are the most widely used antidepressants at present, mainly fluoxetine, paroxetine, sertraline, fluvoxamine and citalopram. SSRI is a selective serotonin reuptake inhibitor, and its main pharmacological function is to selectively inhibit serotonin reuptake and increase the content of serotonin in synaptic cleft significantly.

Citalopram is a relatively minor adverse reaction among SSRI drugs, while escitalopram oxalate is a purified product of citalopram, with fewer adverse reactions and relatively quick curative effect.

Especially in the treatment of senile depression, it is recognized as the first choice for senile depression because of its relatively small impact on chronic diseases such as hypertension and cardiovascular diseases.

The possible adverse reactions of escitalopram oxalate are similar to those of other SSRI drugs, mainly including:

Gastrointestinal tract: nausea, vomiting, anorexia, diarrhea, constipation;

Nervous system: dizziness, headache, anxiety, nervousness, insomnia, fatigue, dry mouth, sweating, tremor;

Allergic reaction: rash;

Sexual dysfunction: impotence, delayed ejaculation, lack of pleasure;

Other symptoms: leukopenia, rare hyponatremia.

Possible adverse reactions are only possible. Generally, patients who take escitalopram oxalate rarely have obvious adverse reactions.

Choice of other drugs

In fact, the drug treatment of depression has always been individualized, with the purpose of being the most suitable for oneself, the best curative effect and the least adverse reaction. In general, it is best to choose citalopram, venlafaxine, sertraline and other drugs in the acute stage of depression, which are relatively quick to take effect; Duloxetine is the best choice for patients with obvious somatization symptoms; Escitalopram oxalate is the safest for patients with hypertension. Venlafaxine plus mirtazapine is the best treatment for refractory suicide patients. The best curative effect of patients with bipolar depression is olanzapine+fluoxetine.

Your doctor will only help you choose treatment drugs according to the characteristics of your illness, so there is no best medicine, only the best doctor.

Depression is a common mental disorder with high incidence, which can be caused by many reasons. The main clinical features are marked and persistent depression, lack of interest, slow thinking, decreased speech and lack of energy, and are often accompanied by physical symptoms, cognitive or psychomotor disorders. Some patients may be accompanied by anxiety and restlessness, and in severe cases, mental symptoms such as hallucinations and delusions may occur. The onset of depression is usually slow. At first, symptoms such as headache, dizziness, insomnia and loss of appetite may appear, and then gradually develop into symptoms such as depression, anxiety and doubt. Usually, the symptoms are heavy in the morning and light in the evening, and in severe cases, suicidal tendencies may appear.

Drug therapy is an effective method to treat depression. At present, drugs for treating depression are mainly divided into five categories, namely selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, norepinephrine and specific serotonin reuptake inhibitors, serotonin reuptake inhibitors and tricyclic antidepressants. So which of these drugs is effective in treating depression and has few side effects? Pharmacist Sun will give you a brief introduction today.

In a word, depression is a common clinical emotional disorder. At present, drug therapy is the main treatment. Among the therapeutic drugs, fluvoxamine, escitalopram, venlafaxine and mirtazapine have strong antidepressant activity, and are suitable for all types of depression, including severe and refractory depression, with few and mild side effects and good safety and tolerance for long-term use.

References:

Guidelines for the Prevention and Treatment of Depression (2006)

What drugs have good effects and small side effects in treating depression? In fact, there is not necessarily a clear answer to this question, because drugs that take effect quickly will definitely have a wider effect from the receptor, so the side effects will definitely be a little bigger.

Monoamine oxidase inhibitors and cyclic antidepressants have basically lost their competitiveness because of their side effects. Let's focus on SSRI and SNRI.

As clinicians, many times we think that venlafaxine, mirtazapine and duloxetine have significant therapeutic effects because they act on 5-HT and ne receptors at the same time, but their disadvantages may be more obvious than other drugs. In fact, careful analysis is not the case.

Depression can be simply divided into three subtypes: typical depression, hidden depression and depression with mental symptoms. Choosing different antidepressants according to the three subtypes can often make the treatment effect better and more accurate.

Typical depression is characterized by "low mood", and then there are characteristics such as decreased interest, slow thinking and depression. For typical depression, we usually have more drugs to choose from, and almost all clinical first-line drugs can be selected.

Recessive depression refers to some atypical depression, such as physical discomfort; Some features are dizziness, fatigue or lack of energy. According to subtype selection, these patients may be more sensitive to antidepressants with activating properties, such as fluoxetine, venlafaxine and duloxetine. Even a small dose of aripiprazole can be added to the refractory individuals.

For depression with psychotic symptoms, it is suggested to avoid using drugs that can increase norepinephrine (ne), because increasing NE may make patients more excited.

In addition, many patients with brain trauma may have similar depressive symptoms. At this time, it is best to avoid using antidepressants that are easy to cause convulsions or epilepsy, such as tricycles and bupropion.

Answer the subject's question, which medicine has less side effects?

At present, SSRI is the main clinical first-line drug. In SSRI, citalopram, escitalopram and sertraline have relatively good tolerance to the body, and there is little interaction between pharmacokinetics. However, compared with the three drugs, citalopram may prolong the Q-T interval of the heart when it exceeds 40 mg per day. Theoretically, the risk of accidents is higher than the first two drugs.

To sum up, duloxetine with dual-channel effect, namely venlafaxine, has better effect and takes effect faster, but everyone has different emphasis on the side effects of drugs, so it is difficult to generalize which side effects are smaller.

Generally speaking, if patients are afraid of getting fat, fluoxetine and bupropion have less side effects;

For patients who are worried about sexual dysfunction, in order to avoid SSRI, bupropion or mirtazapine can be chosen;

For patients who are worried about cardiovascular diseases, duloxetine, venlafaxine and citalopram should be avoided, and sertraline should be chosen as an auxiliary;

Those with a history of epilepsy should avoid bupropion;

If the subject's question is: a treatment with good effect and little side effects, I will answer it-non-convulsive electroconvulsive therapy. I believe that patients who have taken this treatment plan will have some experience. Simple electroconvulsive therapy does avoid the influence of drug accumulation on liver and kidney, and has the advantage of quick effect, but the biggest disadvantage is that the treatment cost is relatively high.

I hope my answer is helpful to you, please pay attention, and I will update the relevant questions every day.

Depression is difficult to cure, and the main reason for its recurrence is that psychological factors have not been removed. Drugs only control part of the symptoms of the disease, and may recur under the stimulation of social and psychological factors. Therefore, it is suggested that it is best to use drugs combined with psychotherapy to achieve a good therapeutic effect, and at the same time, treat the disease fundamentally to achieve a satisfactory therapeutic effect. The reason of recurrent disease is that psychological factors are not treated, and only by removing psychological factors can a radical cure be achieved.

As a patient with depression for ten years, talk about my medication experience.

My personal experience is that, in general, the side effects of antidepressants with higher prices are relatively small. I have used venlafaxine and paroxetine, and the side effects of these two drugs are only discomfort in the first few days, dry mouth and bitter taste. After a few days, I got used to it without any discomfort.

Moreover, these two drugs are also very effective and independent.

Some drugs vary from person to person, such as mirtazapine, which is mainly used to treat depression patients with severe insomnia. When I use mirtazapine, it works well. Sleep well after taking mirtazapine, and taste failure when using mirtazapine. Almost everything tastes the same. The most important thing is that I gain weight quickly when I use mirtazapine. Under normal circumstances, it takes at least a few months for antidepressants to stop taking drugs, so I won't take mirtazapine easily unless I have to endure severe insomnia, because every time I take mirtazapine, the whole person will gain twenty or thirty pounds, or even more.

But this medicine is different for everyone. Some patients who take mirtazapine like me are not fat.

So my personal experience is that venlafaxine and paroxetine have small side effects, good effects and acceptable prices.

Method of choosing antidepressants:

Citalopram is used for the elderly with poor constitution.

Sertraline is used to treat depression with mild anxiety.

Paroxetine is used to treat depression with severe anxiety.

Fluoxetine is used for people with insufficient motivation.

Venlafaxine is used for psychotic symptoms.

Mirtazapine is used to treat sleep disorders.

Duloxetine is used in patients with hypotension.

Amitriptyline is used for poor economy, anxiety and insomnia.

Use new drugs with caution, because any drug needs a long observation process. ...

It's best not to be depressed.

The treatment of depression needs face-to-face consultation.

The above is not the doctor's advice.

Everyone has different symptoms and takes different medicines, so make yourself better. The doctor will look at the size of the side effects.

If you don't take medicine, your body will be damaged, which is not much worse than taking medicine.