Why do people get frostbite?

The reason for the gradual freezing is unknown until June 2020 10. 20% of cases may be related to heredity and genetic defects. In addition, some environmental factors, such as heavy metal poisoning, may cause motor neuron damage. At present, the main theories about the causes of motor neuron injury are:

1. neurotoxic substances accumulate, and glutamic acid accumulates between nerve cells, which will cause damage to nerve cells over time.

2. Free radicals destroy nerve cell membranes.

3. Lack of nerve growth factor makes nerve cells unable to grow and develop continuously.

Extended data:

"Frozen people" is characterized by progressive degeneration of motor nerve cells (neurons) in the brain and spinal cord. Because motor neurons control the activities of muscles that enable us to move, speak, swallow and breathe, if there is no nerve to stimulate them, muscles will gradually atrophy and degenerate, which is manifested as muscles will gradually weaken or even paralysis.

And speech, swallowing and respiratory function decline until death due to respiratory failure. Because the sensory nerve is not invaded, it will not affect the intelligence, memory or feeling of the patient. The development of this disease is usually rapid and ruthless. From the onset of symptoms, the average life expectancy is between 2 and 5 years.

Baidu Encyclopedia-Five Deadly Diseases in the World

Baidu encyclopedia-amyotrophic lateral sclerosis