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The complexity of mastitis pathogens determines the difficulty of treatment, but the general principle of treatment is to eliminate the etiology and pathogens and enhance the body's resistance.

At present, antibiotics, sulfonamides and furans are widely used at home and abroad to eliminate pathogens.

However, there are also many cases with unsatisfactory therapeutic effect or long-term incurable.

The reasons are as follows: First, no effective treatment scheme is selected according to the disease (acute, chronic and recessive), symptoms (whether there are systemic symptoms) and the onset period (lactation period and lactation period); Secondly, the diagnosis and treatment is delayed, and irreversible lesions have occurred in breast tissue.

Third, the causes and pathogens have not been completely eliminated.

Especially when eliminating pathogens, the blindness of medication is the root cause of poor curative effect.

Therefore, it is very important to choose targeted drugs that are highly sensitive to pathogenic bacteria.

According to the drug sensitivity experiments and treatment experiments of scholars at home and abroad, the drugs sensitive to mastitis pathogens are as follows.

Staphylococcal mastitis can be treated with chloramphenicol, erythromycin and kanamycin, and then neomycin.

Mastitis caused by streptococcus can be treated with streptomycin, kanamycin and cycloserine.

Mastitis caused by Klebsiella and Pseudomonas aeruginosa can be treated with gentamicin.

Mastitis caused by Clostridium perfringens can be caused by tetracycline, Nocardia mastitis, long-acting sulfanilamide and penicillin.

Before determining the pathogen, the mixed solution of penicillin and streptomycin was injected into the nipple tube after milking (500,000 units of penicillin and 200mg of streptomycin were dissolved in150-200ml distilled water) twice a day.

After the injection, hold the nipple base with your hand and gently massage upward to make the liquid medicine spread upward. In severe cases, 2-2.4 million units of penicillin can be injected intramuscularly, 2-3 times a day.

If necessary, add streptomycin, or apply gentamicin and erythromycin. If penicillin injection fails, inject 0. 1% rifeno solution or 0. 1% furbucillin solution150-200ml.

For different types of mastitis, the Soviet Union proposed to treat it with propolis preparation.

The preparation method comprises soaking propolis in 96% alcohol, and the amount of substance is not less than 50%. After soaking for 24 hours, stirring, filtering with double gauze or filter paper, and then preparing 2% and 5% propolis oil.

The proportion of 2% propolis oil is lanolin10g, 4 ml of propolis extract and 86 ml of cod liver oil.

The ratio of 5% is 20g lanolin,10ml propolis extract and 70ml cod liver oil.

Mastitis is usually treated with 2% propolis oil, which is injected into the milk pool 7 10 ml each time, three times a day.

5% propolis oil was used to treat suppurative, hemorrhagic and cellulosic mastitis, and the injection dosage and time were the same as above.

The bacteriostatic experiment and clinical treatment made by animal husbandry and veterinary of Shandong Academy of Agricultural Sciences show that propolis has a good effect on staphylococcal mastitis.

For chronic mastitis, Japan proposes to treat it with levamisole hydrochloride, giving 7.5 mg per kilogram of body weight, dissolving it in water and taking it orally. The mechanism of action of levamisole hydrochloride is not to directly inhibit or kill pathogenic bacteria, but to enhance the immune defense system of the body, enhance the response of lymphocytes and phagocytosis of macrophages.

In addition to medication, we should also pay attention to increasing milking times to reduce the pressure and burden inside the breast, and limit the feeding of concentrated feed, juicy feed and drinking water to reduce milk secretion.