2020 Licensed Pharmacist Mock Exam Questions: "Professional Knowledge of Traditional Chinese Medicine I" Chapter 3 After Class

"Professional Knowledge of Traditional Chinese Medicine I" is a subject that must be reviewed in preparation for the 2020 Licensed Traditional Chinese Pharmacist Examination. The Global Ivy Licensed Pharmacist Channel has compiled the 2020 Licensed Pharmacist Simulation Test Questions for everyone: After-class exercises for Chapter 3 of "Professional Knowledge of Traditional Chinese Medicine I". I hope the following 2020 licensed pharmacist simulation test questions will be helpful for everyone to learn this part of knowledge!

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2020 Practicing Pharmacist Mock Test: "Traditional Chinese Pharmacy Professional Knowledge 1" Chapter Chapter Three

Chemical composition and pharmacodynamic material basis of traditional Chinese medicine

(Click to download>>Other subjects and chapters 2020 Licensed Pharmacist Mock Exam Questions)

Note: Due to As of the date of publication, the official has not released the 2020 Licensed Pharmacist Examination syllabus and examination materials. The following are the mock test questions compiled by the editor with reference to the 2019 Licensed Pharmacist Examination syllabus and examination materials.

The teaching materials for the 2020 "Professional Knowledge of Traditional Chinese Medicine" exam for licensed pharmacists may change. But time waits for no one. Although the new version of the exam syllabus and teaching materials have not yet been released, everyone is still asked to review in advance based on the 2019 version of the information. You can use the "free appointment text message reminder" provided by Global Ivy, and you will be reminded in the form of text messages when the 2020 Licensed Pharmacist Examination Textbook will be published.

1. Best choice questions

1. Regarding the characteristics of the continuous reflux extraction method, which one of the following is correct

A. Normal temperature or warm (60 ~80%) conditions, suitable for traditional Chinese medicines whose active ingredients are unstable when exposed to heat or contain a large amount of starch, gum, pectin, or mucilage

B. Continuously add fresh solvent to the crushed Chinese medicinal materials at room temperature to consume the solvent Large quantity, time-consuming, and troublesome to operate

C. Add water and boil, which is simple, but it is not suitable for Chinese medicinal materials that contain volatile ingredients or active ingredients that are easy to decompose when heated

D. It is easy to evaporate when used The disadvantage of organic solvent heating and reflux extraction is that it is not suitable for thermally unstable components, consumes a lot of solvent, and is troublesome to operate

E. Soxhlet extractors are commonly used in laboratories, but this method takes a long time

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2. Regarding the following characteristics of the decoction method, which one is correct

A. Normal temperature or warm (60~80℃) conditions, suitable for active ingredients that are unstable when exposed to heat or contain a large amount of Starch, gum, pectin, and mucilage Chinese medicines

B. Continuously add fresh solvent to the crushed Chinese medicines at room temperature, which consumes a large amount of solvent, is time-consuming, and is troublesome to operate

C. Adding water to boil is simple, but it is not suitable for Chinese medicinal materials that contain volatile components or active components that are easily decomposed when heated

D. Use volatile organic solvents to heat and reflux for extraction. The disadvantage is that it is not suitable for thermally unstable components. The solvent consumption is large and the operation is troublesome

E. Soxhlet extractor is commonly used in laboratories. It has the advantages of solvent saving and simple operation, but the disadvantage is that it takes a long time

3. Glycosides, amino acids, etc. Such ingredients are easily soluble in

A, water and hydrous alcohol

B, chloroform, ether, etc.

C, petroleum ether

D. Alkaline aqueous solution

E. Acid aqueous solution

4. Solvent method should be used to extract alicyclic and aromatic compounds such as terpenes and steroids

A. Water and water-containing alcohol

B. Chloroform, ether, etc.

C. Petroleum ether

D. Alkaline aqueous solution

E. Acid aqueous solution

5. After the substances adsorbed by the macroporous adsorption resin are fully eluted with water, they are then eluted with acetone. The substances washed out by acetone are

A. Monosaccharides

B, tannins

C, polysaccharides

D, neutral lipophilic components

E, amino acids

< p>6. The principles of two-phase solvent extraction to separate components in a mixture include

A. Different structural types of each component

B. Different distribution coefficients of each component

C. The chemical properties of each component are different

D. The polarity difference between the two-phase solvents is large

E. The polarity difference between the two-phase solvents is small.

7. Under normal circumstances, the elution capabilities of various solvents on polyamide columns range from weak to strong and can be roughly arranged in the following order

A. Water? Methanol? Acetone ?Formamide?Sodium hydroxide aqueous solution?Dimethylformamide?Urea aqueous solution

B. Methanol?Water?Acetone?Sodium hydroxide aqueous solution?Formamide?Dimethylformamide?Urea aqueous solution

B. p>

C. Methanol? Urea aqueous solution? Acetone? Sodium hydroxide aqueous solution? Formamide? Dimethylformamide? Water

D. Water? Methanol? Acetone? Sodium hydroxide aqueous solution? A Amide? Dimethylformamide? Urea aqueous solution

E. Water? Methanol? Acetone? Dimethylformamide? Formamide? Sodium hydroxide aqueous solution? Urea aqueous solution

8. The material basis for Chinese medicine to prevent and treat diseases lies in its content

A, water-soluble ingredients

B, active ingredients

C, amino acid ingredients

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D. Polysaccharide components

E. Fat-soluble components

9. Which substance is most suitable for separation by polyamide chromatography

A. Sterols

B. Cardiac glycosides

C. Saponins

D. Alkaloids

E. Flavonoids Category

10. The solvent system of adsorption column chromatography can be screened by TLC. The Rf value must comply with

A, 0.1～0.2

B, 0.3～0.4< /p>

C, 0.2～0.3

D, 0.4～0.5

E, 0.5～0.6

11. Adsorbent and

The adsorption strength and sequence of the compounds to be separated generally follow

A. Those with large polarity differences are easy to adsorb

B. Similar ones are not easy to adsorb

< p>C. Those with small polarity differences are not easy to adsorb

D. Similar ones are easy to adsorb

E. Similar ones are compatible

Best multiple choice answer< /p>

1.

Correct answer E

Answer analysis The continuous reflux extraction method makes up for the disadvantages of large solvent consumption and troublesome operation in the reflux extraction method. It is commonly used in laboratories. Soxhlet extractor is used to complete this method. But this method takes longer.

2.

Correct answer C

Answer analysis The decoction method is a method in which Chinese medicinal materials are soaked in water and then heated and boiled to extract the active ingredients. This method is simple, but this method should not be used for Chinese medicinal materials that contain volatile components or active components that are easily decomposed when exposed to heat.

3.

Correct answer A

Answer analysis When using solvent extraction method to extract and separate components, terpenes, steroids and other alicyclic and Aromatic compounds are easily soluble in lipophilic solvents such as chloroform and ether due to their low polarity; glycosides, amino acids and other components are highly polar and are easily soluble in water and hydrous alcohols; acidic, alkaline and amphoteric compounds are Because the state of existence (molecular or ionic form) varies from solution to solution, solubility will change with pH.

4.

Correct answer B

Answer analysis When using solvent extraction method to extract and separate components, terpenes, steroids and other alicyclic and Aromatic compounds are easily soluble in lipophilic solvents such as chloroform and ether due to their low polarity; glycosides, amino acids and other components are highly polar and are easily soluble in water and hydrous alcohols; acidic, alkaline and amphoteric compounds are Because the state of existence (molecular or ionic form) varies from solution to solution, solubility will change with pH.

5.

Correct answer D

Answer analysis: Selection of eluent for macroporous resin.

6.

Correct answer B

Answer analysis Examine the separation principles of different methods.

Two-phase solvent extraction (or liquid-liquid extraction) is a method that uses the different distribution coefficients of the components in the mixture in two mutually immiscible solvents to achieve separation. Usually one phase is water. (including acid water or alkaline water), and the other phase is an organic solvent that can separate from water.

Summary of the principle of separation:

(1) Separation (recrystallization) based on the solubility difference of substances;

(2) According to the separation of substances in two-phase solvents Separate according to different distribution ratios (distribution coefficients) (reverse-phase chromatography packing, pH gradient extraction);

(3) Separate according to differences in boiling points of substances (fractionation method);

( 4) Separate substances based on differences in adsorption (adsorption chromatography);

(5) Separate substances based on differences in molecular size (gel filtration chromatography, membrane separation);

( 6) Separate substances according to their different degrees of dissociation (ion exchange chromatography).

7.

Correct answer D

Answer analysis In general, the elution capabilities of various solvents on polyamide columns range from weak to strong. Roughly arranged in the following order:

Water? Methanol? Acetone? Sodium hydroxide aqueous solution? Formamide? Dimethylformamide? Urea aqueous solution.

8.

Correct answer B

Answer analysis The material basis for the ability of traditional Chinese medicine to prevent and treat diseases lies in the active ingredients it contains.

9.

Correct answer E

Answer analysis The adsorption of polyamide to general phenols and flavonoids is reversible (except for tannins), and separation Due to its good effect and large adsorption capacity, polyamide chromatography is particularly suitable for the preparation and separation of this type of compounds.

10.

Correct answer C

Answer analysis Because the surface area of ??the adsorbent used for TLC is generally about twice that of column chromatography, the general TLC development time A solvent system that achieves a component Rf value of 0.2 to 0.3 can be selected as the best solvent system for column chromatography separation of the corresponding component.

11.

Correct answer D

Answer analysis In terms of static adsorption, when an adsorbent is added to a certain Chinese medicine extract, the surface of the adsorbent That is, competition between solute molecules and solvent molecules, as well as solute molecules for the adsorbent surface, occurs. The physical adsorption process is generally non-selective, but the adsorption strength and sequence generally follow the empirical rule that "similar objects are easier to adsorb".