My favorite male colleague is drinking at a party tonight. I want to send him a message to drink less. He looks terrible recently. How to send it is better. He will.

What message are you sending? You should encourage him to drink more wine and try to get him drunk. If he is pretending to be drunk, it means that he likes you and wants to talk to you tonight. If he doesn't want to get drunk and want to leave as soon as possible, explain what you know ...; If he is drunk, it's up to you whether to do it to him or not. The above are just suggestions, and you have to consider them yourself in the end.