Why do kindergartens check hepatitis B antibodies, and 80% of children have no antibodies?

Every baby is vaccinated against hepatitis B. The purpose is to produce hepatitis B antibodies and protect infants from hepatitis B virus infection. But why are some babies vaccinated with hepatitis B vaccine or without antibodies?

No antibody is produced after hepatitis B vaccination, which means that hepatitis B surface antibody (HBsAb) is negative or weakly positive after the whole course of hepatitis B vaccination, with an interval of more than two months.

The anti -HBs concentration 1~3 months after the first full immunization of hepatitis B vaccine > = 10 mIU/mL, which can be considered as a reliable serological marker for long-term prevention of HBV infection, indicating that the antibody is effective.

In 20 18, the American Advisory Committee on Immunization Practice also pointed out in its proposal on preventing HBV infection:

A negative antibody on the surface of hepatitis B indicates no antibody production, and a weak positive indicates insufficient antibody production. Both cases indicate that the human body has no specific immunity to hepatitis B virus.

The reasons for the failure of hepatitis B vaccine immunization are complicated, which can be divided into two aspects: vaccine factors and organism factors.

1, vaccine factor

The type and quality of vaccine, the location and route of vaccination, the procedure and dosage of vaccination directly affect the vaccination effect. Pay attention to the following points when vaccinating hepatitis B vaccine:

① The inoculation site should be in the deltoid muscle of the upper arm, because there is much fat in the buttocks, most of the vaccine is absorbed by the adipose tissue after hip injection, and the adipose tissue is not easy to store, so the response rate of hip injection is lower than that of upper arm injection;

② Shake the hepatitis B vaccine before inoculation, because the HBsAg in the hepatitis B vaccine is adsorbed on the aluminum hydroxide adjuvant and precipitated at the bottom of the bottle, and there is no HBsAg in the supernatant;

③ Hepatitis B vaccine should be stored in refrigerator at 4℃ for 2 years;

④ We should adhere to the whole course of 3-needle immunization, and the vaccination program is 0, 1 and 6 months, which can achieve good immunization effect.

2. About the child's physical factors.

① Genetic factors

Most scholars believe that HBsAg carriers are familial aggregation, which may be autosomal recessive inheritance. The occurrence of no (low) response after vaccination with hepatitis B vaccine is related to HLA typing and locus. Individuals with HLA-DR3+ or HLA-DR7+ phenotypes have a higher probability of low response after vaccination with hepatitis B vaccine.

② Variation of hepatitis B virus

If the antigenic determinant α related to anti -HBs induced by hepatitis B vaccine mutates, the binding force between antibody and mutated hepatitis B virus surface antigen decreases, which may lead to the failure of immune protection of hepatitis B vaccine.

③ Hepatitis B vaccine has no (low) response cytological basis.

People who have a good immune response to hepatitis B vaccine have a good immune response to recombinant hepatitis B virus surface antigen and have the activity of stimulating the proliferation of recombinant hepatitis B virus surface antigen. However, those who have no (low) response to hepatitis B vaccine have no obvious proliferative response (abstract, everyone can understand that there is something wrong with the immune system).

④ Hepatitis B virus intrauterine infection.

Hepatitis B virus intrauterine infection is an important reason for the failure of neonatal vaccination. Domestic and foreign data reported that the intrauterine infection rate was as high as 13%-44%. The possible mechanism is that fetal exposure to hepatitis B virus antigen leads to immune tolerance to hepatitis B virus, T cell tolerance leads to low cellular immune function, specific stimulation to hepatitis B virus surface antigen, and insufficient secretion of interleukin -2 and expression of interleukin -2 receptor.

No antibody is produced after hepatitis B vaccine injection, or the antibody produced is not enough. The treatment method should be decided according to the specific situation.

1. For adults with low immune function or unresponsiveness, the inoculation dose (such as 60μg) and injection times should be increased.

2.3 If the vaccination scheme fails, you can get 1 60μg or 3 doses of 20μg hepatitis B vaccine.

3. After the second vaccination with hepatitis B vaccine 1-2 months, the serum HBsAg should be detected. If there is still no response, you can vaccinate again with 1 needle recombinant yeast hepatitis B vaccine.

4. For people with insufficient antibodies, you can strengthen the injection of hepatitis B vaccine.

To supplement and strengthen the hepatitis B vaccine, hepatitis B surface antibody testing will be done two months later. For some people who have produced a little antibody but not enough, it may take longer to produce antibodies slowly.

If repeated injections of hepatitis B vaccine, such as more than three times, still do not produce antibodies, such people may not have more ways to try to use imported vaccines.

It is important to emphasize that some people are very anxious about never producing antibodies, and they are not concerned about the fact that they are not infected. You know, there are still many people in the world who have no antibodies, and they have never been infected with hepatitis B in their lives.

For these children, parents struggle with the fact that they have no antibodies every day. It's really unnecessary!

Leadership? The child injected hepatitis B vaccine, why didn't he produce antibody?

After the baby is born, the first dose of hepatitis B vaccine should be injected within 24 hours, the sooner the better. After that, the second and third injections were completed in the first and sixth months of the child's life. Generally, two to six months after injection, the antibody titer should be rechecked for the child to determine whether the child has immunity.

Many parents will check two and a half pairs for their children before they enter kindergarten, because there are more people in contact and the children have to eat at school. However, many parents find that their children have no resistance. Obviously injected with hepatitis B vaccine, a lot of stitches. Why don't they produce antibodies?

Because my children were examined by two and a half teams when they first entered school, and there were no antibodies. So I checked some information, and the child didn't produce antibodies, probably because the injection dose was not enough, the child's immunity was poor, and some drugs to suppress immunity were used during the child's illness. The most important reason is his own immune tolerance.

Generally, children who are not negative for anti -HBs are required to be vaccinated again, and vaccinated three times according to the time law of hepatitis B vaccination, 0 1 6, until the children produce antibodies.

After the child is vaccinated with three doses of vaccine, he can't go to check and test immediately, and wait until the child is vaccinated for two and a half months until the child produces antibodies. China is a big country of hepatitis B itself, and vaccination against hepatitis B is the main way to protect children's health. However, the injection of hepatitis B vaccine is not once and for all. As time goes by, the antibody will gradually decrease. This is also why many adults and children checked hepatitis B antibodies a few years ago, and there was no antibody after a few years.

It is recommended to check it every three or four years, and replant it in time when the antibody disappears.

Vaccination of hepatitis B vaccine is the most effective means to block mother-to-child transmission of hepatitis B virus. Intramuscular injection of recombinant yeast hepatitis B vaccine 10ug or 20ug Chinese hamster oocyte (CHO) hepatitis B vaccine within/0/2 hours after delivery (preferably within 6 hours), 30% of the children can form antibodies. One month after delivery, the newborn was injected with recombinant yeast hepatitis B vaccine 10ug or 20ug Chinese hamster oocyte (CHO) hepatitis B vaccine again, and 50%~70% of the children produced antibodies. At the age of six months, the newborn was injected with recombinant yeast hepatitis B vaccine 10ug or 20ug Chinese hamster oocytes (CHO) hepatitis B vaccine for the last time. More than 90% of children can get antibodies. If pregnant mothers at home are positive for HBsAg and HBeAg (highly contagious), they can be injected with HBIG (hepatitis B immunoglobulin) 100~200IU intramuscularly within six hours after delivery, and complete the immunization program (0- 1-6) according to the above immunization plan, and 95%~98% of the children can get immune protection.

If 80% of children in a kindergarten do not produce hepatitis B antibodies, such a situation needs to be investigated for responsibility. Most children in kindergarten are 3-5 years old. Under normal circumstances, the protective effect of people with antibody reaction after vaccination with hepatitis B vaccine can last at least 12 years. In other words, these children have no immune protection. Then there are nothing more than two possibilities: 1, not vaccinated according to the immunization plan. 2. The vaccine is invalid. If you don't vaccinate according to the immunization plan, you should know the antibody situation in your body. If the anti-HBS antibody is found to be lower than 10mIU/ml, it is necessary to strengthen immunization. However, if there is no anti-HBS antibody, the inoculation process of (0- 1-6) needs to be repeated. If the vaccine is ineffective, it needs to be repeated outside the immunization program (0- 1-6). It is also necessary to trace whether the vaccine is refrigerated and rule out the possibility of fake vaccines.

Children are the future of the motherland, and their health is no small matter. Only by sorting out the causes in time and taking necessary measures to remedy them in time can we avoid their health damage. I wish the babies health and safety.

When we went to get the vaccine,

What the staff told me is that the hepatitis B vaccine has been used until the age of three.

After the child is three years old, vaccination will not work.

This means that there are no antibodies, so we need to take a blood test and then re-inoculate.

But if you vaccinate again, you will have to pay.

No more free hepatitis B vaccine.

Later, I heard that it is difficult to have antibodies without giving three injections at my own expense.

My children have been vaccinated free of charge in the country, but there are still no antibodies.

Later, I had three injections at my own expense, and after one year, I was still 1000 antibody.

Of course, it is because of everyone's physical differences.

Maybe some babies still have antibodies when they are three years old.

And some babies have no antibodies when they are over two years old.

Therefore, it is recommended that the baby can review the hepatitis B antibody after 2 and a half years old.

If not, it is necessary to re-vaccinate the paid hepatitis B vaccine.

As for whether the free hepatitis B vaccine is a fake vaccine,

We don't know this. '

This is not necessarily true. When we entered the kindergarten for physical examination, we had antibodies. It is understandable that hepatitis B antibody is insufficient, but it is definitely not possible without antibody. In our country, there are people who have no antibodies after hepatitis B, but there are very few, and it is impossible for 80% of people to have no antibodies.

Generally speaking, it is possible that there is insufficient hepatitis B antibody. However, it is said that children have insufficient hepatitis B antibodies, and they need to do hepatitis B twice and a half or five times to quantify hepatitis B. There are specific data to prove that hepatitis B antibodies are insufficient. Without any data, it is said that the child has insufficient hepatitis B antibody, which is definitely a set of hepatitis B enhancers.

This situation exists in some areas, because many kindergartens are in the health centers where vaccines are given, so this situation will occur. Please look at the data and speak. There is no data to prove that hepatitis B antibody is insufficient. Please be skeptical. Finally, find a big hospital to do hepatitis B five quantitative or hepatitis B two and a half.

Say a real example, a friend's child went to kindergarten and said that the antibody against hepatitis B was insufficient. His friend didn't believe that there was no data in the physical examination, so he went to the local third-class hospital to do five quantitative tests for hepatitis B. The results show that the data of hepatitis B antibody is not only within the range, but also very high.

That's true. Many children have just gone to kindergarten, and when they go to the physical examination, they will find that there is no hepatitis B antibody, and the kindergarten will especially remind them to check this.

I remember that after the child finished three shots of hepatitis B, he added another shot for insurance. Results There were still no antibodies during the physical examination. I had to get four more injections.

I also asked this question at that time, why didn't I have hepatitis B antibody? The doctor said it has something to do with personal physique and the dose of vaccine. However, this situation is too common for my children, and there is no problem. After three injections, there will usually be antibodies.

Sure enough, I checked the child again after the fight, and there were antibodies. However, there is no guarantee how long this antibody will last. Sometimes, I privately wonder if I have a fake vaccine. After all, it happened in Shandong!

Naming is a very important thing, so many parents will try their best to master some specific naming methods. But in fact, you can't get a name without your five elements. You must know what your life is in the five elements. The grand plan name gives you several points for attention. I hope everyone can pay attention to it when naming, and give an ideal name.

First, pay attention to the words when naming your baby.

Chinese characters are one of the most widely used and longest used characters in the world. Up to now, it has a history of more than 6,000 years, and various similar expressions were formed during Mu Tong's cutting period. It coexists in today's real life and is used by people. As a carrier of culture and information, it records the long history and splendid culture of our country and still plays an important role in our national construction and daily life. Hanning also has the advantages of beautiful figure and strong friendship, but also has the problems of many strokes, difficult to recognize, difficult to write and difficult to remember. Therefore, how to combine the limitations of China umbrella and use the convenient name of Xiang Liu is also an aspect that we must consider when naming.

The child obviously played hepatitis B vaccine, why did he check out no antibodies when he went to kindergarten?

Hepatitis B vaccine can not be used for a lifetime, and because each child's physique is different, the dose of the vaccine is different, and the antibody exists for different times. The best way is to give your baby a screening for hepatitis B antibody every two to three years, and if there is no antibody, take another vaccine.

When the baby was two years old, he planned to send it to kindergarten because there was no one to help take care of the child. We should have a physical examination before entering the park. At that time, we thought that children's vaccines were made regularly, and regular physical examinations should be no problem. Who knows the result came out, but it is beyond our medical scope. The doctor said that the baby has no hepatitis B antibody.

At that time, Bao Dad and I were puzzled. Since the baby is born, it is necessary to inject hepatitis B vaccine regularly. How can there be no antibodies? Later, was there a problem with the vaccine? I asked the doctor to know that the dose of neonatal vaccination is generally small, and the hepatitis B vaccine can only last for about three years. In addition, each baby's physique is different, so the time of antibody existence is also different. This is normal.

The best way is to give your baby a regular physical examination every year, so that you can find the problem in time and replant the vaccine in time.

/kloc-within 0/2 hours, the child should register for hepatitis B vaccine as soon as he is born, and then take it once a month, three times in a row.

At present, hepatitis B vaccine is the most effective method to prevent hepatitis B infection. With antibodies, hepatitis B vaccine will not be infected.

Most people will produce antibodies after three injections of hepatitis B vaccine, and very few will not produce antibodies. In addition, don't think that there will be antibodies after the hepatitis B vaccine. Even if there were antibodies, they might disappear after a year or two. Therefore, it is still necessary to have a physical examination once a year to see if antibodies still exist. If there is no antibody, it is recommended to supplement it.

Kindergarten belongs to collective life, and everyone usually eats and drinks water, so it is necessary to check hepatitis B antibody in kindergarten.

It's impossible that 80% people don't have antibodies. If 80% have antibodies, that's normal. Generally, three shots of hepatitis B vaccine are given. Why do you have three shots? It is because of that% ratio that most people will produce antibodies after three injections, but some people still don't. Therefore, after three injections, blood tests will be taken in a few months. If there are antibodies, you don't have to fight. If there is no antibody, you have to continue taking it. Under normal circumstances, it can be guaranteed for 10 years, and then you can have another antibody blood test and another injection 10 years. Although the warranty period of imported products is 15 years, it is better to have annual inspection on 10 for safety.