Treatment scheme of blue ear disease

Swine disease: treatment scheme of blue ear disease

Conclusion 1:

Although vaccine is an effective method to control the virus, there is no guarantee that blue ear disease will not occur after vaccination. Because blue ear disease virus is easy to produce sub-virulent strains and subgroups, it is easy to break out when there are foreign pigs or the antibody titers in the whole field are inconsistent. It is possible that some attenuated vaccines for blue ear disease will recover their strength after injection, which will lead to the occurrence of blue ear disease. If more than 70% sows in the pig farm have high neutralizing antibody titers, maternal antibodies can be transferred to piglets. Therefore, before deciding whether to vaccinate, the titer of sow antibody should be determined. Sows are vaccinated (usually attenuated), and if they are infected with virulent strains, they will also spread to piglets through placental infection and develop blue ear disease.

Large and medium-sized pig farms usually adopt the following methods to control the sudden outbreak of porcine blue ear disease.

A. adding drugs into the feed, namely compound anthocyanin1000g+tylosin 600g+doxycycline 300g/ton. ..

B. Treatment of persistent high fever pigs: compound anthocyanin1000g+taurine 2000g+aspirin1000g/1000kg is soaked in clean water for 3-5 days. Try not to give pigs injections to prevent stress from causing heart failure.

C. Strengthen disinfection: disinfect with acid-containing disinfectants (such as peracetic acid) every day, and use other disinfectants after a period of time.

D. After the epidemic disease of pigs is stable, it is suggested that the whole pig herd should be vaccinated with swine fever vaccine once. In order to avoid inoculation pressure, you can inoculate several times. (If five seedlings are inoculated, two seedlings should be inoculated first, and three seedlings should be inoculated after three days).

E. After the pigs are stable, it is required to do a good job in drug health care, strengthen nutrition, disinfect frequently (once every 2-3 days), and do not vaccinate indiscriminately.

Conclusion 2:

When blue ear disease tends to be stable in pig farms, what should farmers do once blue ear disease breaks out in surrounding pig farms or individual pig herds? How to control the loss to a minimum? How to take emergency measures?

emergency response

First find out why.

We can start with the control loop.

Blue ear disease mutant is one of the main pathogens of swine high fever, but it does not mean that high fever is equal to highly pathogenic blue ear disease. Therefore, if the high fever is mainly caused by the mutant strain of blue ear disease, the epidemic prevention of blue ear disease should be given priority to, that is, the sick pigs should be separated from the pigs without clinical manifestations, and the sick pigs can be treated with traditional Chinese medicine, so antibiotics should be used with caution at this time. Pigs with no clinical manifestations can be vaccinated with live blue ear disease vaccine. ? Professor Cai from Harbin Institute of Veterinary Medicine, Chinese Academy of Agricultural Sciences said that he did not participate in the study of variant strains of blue ear disease. Pig has a high fever? After laboratory diagnosis, corresponding measures should be taken according to the characteristics of the main pathogens diagnosed. Must symptomatic treatment be adhered to? Slow defecation, slow fever? The principle of.

Once blue ear disease breaks out, it is difficult for first-line pig farms to stabilize the epidemic quickly. Song Changxu, deputy director of the Veterinary Research Institute of Guangdong Academy of Agricultural Sciences, believes that it is not very rational to start from the blue ear disease itself in the pig farm where the blue ear disease broke out, and there will also be unsafe factors in how to deal with it. He suggested that we should consider investigating the infection of circovirus at the scene. There is often a synergistic effect between the blue ear and the ring. If the ring can be stabilized, the control of blue ear disease will be easier. The immune mechanism of circovirus is very clear, and vaccine is the best method? After the ring is restrained, the control of blue ear disease will become much simpler. ?

In addition, Professor Yang of China Agricultural University also suggested that after the outbreak, the infected pigs/pig houses should be isolated or closed in time (if the number of infected pigs is small, all infected pigs can also be culled), and irrelevant personnel should be prohibited from entering and contacting infected pigs, and the infected pigs (pig houses) should be disinfected. Sick pigs, excrement, contaminated feed, bedding, sewage, etc. Harmless treatment will be carried out in time, and contaminated articles, vehicles, utensils, pig houses, sites, etc. will be treated. Will be completely disinfected. For sick pigs, electrolytic multi-dimensional drinking water can be used in the early stage, and antibacterial drugs and antipyretic drugs should not be used. At the same time, sick pigs should not be vaccinated. After 3-5 days, the infected pigs can be injected with cephalosporin/kloc-0 once a day for 3 days, so as to control the secondary bacterial infection, which can effectively reduce the death of infected pigs. For other healthy pigs in the diseased pig farm, live attenuated vaccine with good safety can be used for immunization.

Conclusion 3:

Vaccine selection

Classic strain or mutant strain?

Live or inactivated seedlings?

In addition to emergency treatment measures after the onset, vaccine immunization is also very important to control the disease. Domestic experts have different opinions and suggestions on the choice of vaccine. ? According to our research, it usually takes 3-4 weeks for blue ear vaccine to produce antibodies. Although some farmers reported that TJM-F92 blue ear vaccine was effective after emergency immunization, I am still not sure. ? Professor Zhang Guihong of South China Agricultural University said that blue ear virus mainly infects alveolar macrophages of pigs, which can not only cause alveolar macrophages damage, but also stimulate alveolar macrophages to produce antibodies. Because blue-ear virus has specific toxic and side effects on macrophages, relatively speaking, the virulence of classical strain vaccine is weak and the safety is relatively high when used. In addition, the cross-protection between classical strains and highly pathogenic strains also has experimental basis. ? Personally, I suggest to choose the classic strain of blue ear vaccine with high safety for immunization. ?

It is also known that when the highly pathogenic blue ear disease occurred in 2007, an inactivated vaccine was introduced, but many people reported that the inactivated vaccine was ineffective and the live vaccine was considered too dangerous. ? If you want to control blue ear disease as soon as possible, it is recommended to use live vaccine, but the consequence is that negative pig farms will become blue ear disease positive pig farms after using live vaccine, which will increase the complexity of preventing and controlling blue ear disease in the future; However, if inactivated vaccine is used, the problem of virulent blue ear disease cannot be solved quickly. Although the effect is slow, the complexity will become smaller in the future. ? Tian, director of the National Veterinary Medicine Engineering Technology Research Center, said that blue ear disease vaccine, whether live or inactivated, can only reduce the incidence, improve the survival rate and slaughter rate, but can not completely solve the problem of persistent infection and recessive virus carrying. Therefore, in order to achieve the goal of purifying blue ear disease, vaccines cannot be used to solve it.

In order to finally achieve the goal of purifying and eradicating blue ear disease, I personally think that live vaccine must be used? Tian explained that because the effect of live vaccine is better than that of inactivated vaccine, live vaccine should be stopped when the epidemic situation is controlled to a certain extent. Therefore, under the severe epidemic situation of blue ear disease, live vaccine can be used to control it. One day, the live vaccine will be stopped and the inactivated vaccine will be used to control it. At that time, if a major epidemic occurs again, treatment measures such as culling can be taken, and finally blue ear disease can be purified without vaccine, and culled directly when the epidemic occurs.

Professor Liu Fang of Guangxi University suggested? In the blue ear emergency immunization, the second vaccination must be carried out 3-4 days after the first immunization. ?