Shock listing! Shengxue Dacheng soluble powder with high content of colistin sulfate is officially listed!

* * * enjoys * * * and "livestock" is ready to go —— On April 26th, the "2023 Shengxue Dacheng Tangshan Appreciation Meeting and New Product Launch Conference" hosted by Hebei Shengxue Dacheng Tangshan Pharmaceutical Co., Ltd. (hereinafter referred to as Shengxue Dacheng) was successfully held in Shengxue Dacheng Tangshan Company. With the theme of "Antimicrobial Drugs", the conference deeply analyzed the current market situation, development trend, new product research and development direction and a series of focus issues in the animal husbandry and veterinary industry. At the same time, during this meeting, Shengxue Dacheng's latest product, Shengxue Changqing-soluble powder with high content of colistin sulfate was grandly released.

Zhang Yuguo, first-class researcher of Tangshan Agricultural and Rural Bureau, Ling, director of Tangshan Veterinary Bureau, Wang Gezeng, deputy director of Tangshan Veterinary Bureau and Feng Run Agricultural and Rural Bureau, Xie Yingming, secretary/executive director of Shengxue Dacheng Tangshan Company, Li Jiong, general manager/deputy secretary of Shengxue Dacheng Tangshan Company, and nearly 100 customers and friends of Shengxue Dacheng attended the meeting. The meeting also specially invited Professor Liu Juxiang, Dean of Animal Medical College of Hebei Agricultural University, Professor Zhang Jinggan, Deputy Secretary/Associate Research Fellow of Animal Medical College of Hebei Agricultural University, Technical Director of Veterinary 1 14 Network, and Yang Xiaoyong, Executive Director and Secretary General of China Veterinary Innovation Committee of Shandong Animal Husbandry and Veterinary Society. At the same time, the conference also conducted a live broadcast on the online platform, and the cumulative number of online viewers on the live channel exceeded 240,000.

Zhang Yuguo, a first-class researcher of Tangshan Agricultural and Rural Bureau, delivered an opening speech.

Researcher Zhang Yuguo mentioned in his opening speech that Tangshan is a big animal husbandry city, and the output of dairy cows and pigs in the city ranks among the top in the province. The huge number of breeding makes local veterinary drug enterprises show the characteristics of large number and large group. However, with the increase in the proportion of large-scale farming, the tightening of national industrial policy supervision and the improvement of entry threshold for veterinary drugs, the industry has eliminated a number of small-scale family-owned enterprises with poor after-sales service quality. As a major global supplier of colistin sulfate and spectinomycin hydrochloride, Shengxue Dacheng Company has made great contributions to the development of animal husbandry in Tangshan and even the whole country. In recent years, Shengxue Dacheng has adapted to the needs of national industrial development, timely transformed and upgraded, met food safety requirements, and embarked on the road of high-quality development. The safety of livestock products has a long way to go. We must resolutely safeguard the safety of aquaculture production, animal-derived food, public health and ecological environment, and make every effort to build a new pattern of agricultural development in which man and nature live in harmony. It is hoped that Shengxue Dacheng will continue to optimize its industrial structure, enrich its product categories, and constantly develop more efficient and safer products that meet the market demand.

Speech by Wang Gezeng, Deputy Director of Agriculture and Rural Affairs Bureau of Fengrun District

Deputy Director Wang Gezeng said in his speech that Shengxue Dacheng Tangshan Company is a well-known veterinary drug manufacturer in Fengrun District. After 20 years of business development, the company has gained a firm foothold, made pioneering efforts, actively sought development, and made outstanding achievements in production and operation, scientific and technological innovation, safety and environmental protection, and quality management. It has made great contributions to the economic development of Fengrun District. In the future, I hope that Hebei Shengxue Dacheng Tangshan Company can continue to forge ahead, seize opportunities, actively respond to various challenges, and provide better products and services for animal husbandry.

Speech by Xie Yingming, Party Secretary/Executive Director of Shengxue Dacheng Tangshan Company

In his speech, Secretary Xie Yingming pointed out that after 26 years of ups and downs, Shengxue Dacheng Company has now developed into a modern pharmaceutical group with10.5 million employees and a revenue scale of over one billion. Especially in recent years, Shengxue Dacheng entered the fast lane, and quickly entered the field of veterinary drug preparations at the rate of doubling every year for four consecutive years, realizing the leap-forward development from scratch, from existence to perfection and from perfection to Excellence. Shengxue Dacheng has always attached great importance to quality. In the future development process, Shengxue Dacheng will, as always, adhere to the concept of "quality creates value and quality makes brand", spare no effort to pursue quality and provide our customers with quality products, services and solutions!

Liu Juxiang, College of Animal Medicine, Hebei Agricultural University —— Reduction and Substitution of Antibacterials

Professor Liu Juxiang analyzed the current situation and overall situation of antibiotic products in various countries from the international level, and pointed out that antibiotic resistance or AMR is considered as one of the most important public health problems in the world, and it also poses an urgent and serious threat to animal and plant health, food safety and economic development.

According to the usage of veterinary antibacterial drugs in European countries in recent 10 years, the latest ESVAC report published in 200211shows that the sales of antibacterial drugs will drop by more than 43% from 20 1 1 to 2020. This also shows that human cognition of antibacterial drugs is improving. We should really be more aware that the use of antibacterial drugs by animals leads to an increase in bacterial resistance rate, and drug-resistant bacteria can spread interactively between humans and animals. The key measure to reduce the drug resistance of livestock and poultry is the rational use of antibacterial drugs, combined with other measures to effectively protect animal health and production performance. Farmers can also prevent diseases through effective biosafety management and vaccine immunization.

However, antibacterial drugs are not blindly excluded, and three principles should be grasped when using them, namely, reduction, optimization and substitution. Among them, the substitute products of antibiotics mainly include prebiotics, prebiotics, enzyme preparations, organic acids, immune promoters, plant feed additives, plant essential oils, antimicrobial peptides, bacteriophages and so on. And breeding is mainly about learning to choose and use them reasonably.

Teacher Yang Xiaoyong-Key Points of Intestinal Health of Livestock and Poultry

Mr. Yang Xiaoyong pointed out from the beginning that 99% of the nutrients of animals need to be absorbed through the intestine, 80% of the toxins are excreted through the intestine, and 70% of the immunity comes from the intestine. It is of great significance to strictly observe the health status of the intestine.

At present, the main factors affecting the intestinal health of livestock and poultry are: designing feed with commercial thinking rather than animal physiological and nutritional needs. After all, the shortage of feed raw materials leads to the intake of harmful substances, but it is covered up by additives. Pathogenic factors such as pathogenic Escherichia coli, Salmonella, Clostridium enterica, Campylobacter, and viral diseases such as infectious gastroenteritis; Misuse of disinfectants, synthetic detergents, unreasonable drugs and antibiotics; Depending on the risk of blood protozoa, the production performance decreases; Immune stress or stress. Therefore, reasonable measures should be taken to prevent and reduce the occurrence of intestinal diseases, such as providing reasonable nutrition supply to livestock and poultry, controlling the level of harmful substances in feed, reducing stress reaction, reasonable immunization, controlling the level of harmful bacteria, timely and timely deworming, controlling the level of parasites, and using antibiotics scientifically. Among them, the key to the rational use of antibiotics is to choose products with reliable quality first.

In addition, different preparation levels and the application of excipients greatly affect the activity and bioavailability of drugs. For example, lipopeptide and glycolipid can improve the activity of most antibiotics by more than 20%. However, when the body has a major stress or disease state, it will inevitably affect the intestinal flora structure, so the first control level is Clostridium firstly, followed by Escherichia coli. Therefore, the secondary infection of Clostridium should be paid enough attention. It is also very important to fully evaluate the clinical side effects of antibiotics and use them reasonably.

Chen Minglang, chief engineer of R&D of colistin sulfate —— Shengxue Changqing —— Analysis of new products with high content of soluble powder of colistin sulfate

Chief engineer Chen Minglang first introduced the current market situation of soluble powder of colistin sulfate. He introduced that at present, there are probably four problems in 5% and 10% soluble colistin sulfate powder on the market, namely, there are problems such as large dosage, repeated feeding and inconvenient use in large-scale cultivation. At the same time, it does not conform to the concept of "reducing antibiotics"; Directly use colistin sulfate as raw material. Although the dosage is small, it is difficult to monitor the dosage, which is illegal and irregular, posing a great threat to food safety; It is easy to delaminate, the drug effect is difficult to guarantee, the solubility is poor, and it is easy to agglomerate; In clinical use, colistin sulfate products often cause waterline blockage of aquaculture plants.

Shengxue Dacheng new product Shengxue Evergreen has the advantages of fast dissolution, less dosage and safer. Quick dissolution-the new product can be completely dissolved in about 1 minute. Less dosage-compared with soluble powder with low content of colistin sulfate, the new product has more uniform content of colistin sulfate, more stable efficacy, one-time administration, low cost and more convenient use. Safer-Compared with the problems of illegality, non-compliance and insecurity caused by direct use of colistin sulfate, the new product is legal, compliant, safe and effective.

The traditional products and instant products of Shengxue Dacheng were stirred at 1, and the results were quite different. Traditional products are stirred into blocks and rods, which are difficult to dissolve, and a large number of tiny flakes float on the water surface. However, the instant products of spray drying technology quickly disperse after stirring, and do not stick to rods or tiny flakes, which has good solubility. (as shown in the figure below)

Field comparison test display diagram

Looking forward to the future, Shengxue Dacheng will rely on the skeleton of colistin sulfate to directionally transform the molecular structure of colistin sulfate to achieve drug targeting; It will be based on fermentation, with extraction as the core and effect-oriented. Reform the extraction process, strengthen the intervention in each stage of molecular conformation of colistin sulfate, and realize the fine control of drug life cycle; Cooperate with universities or R&D institutions, * * * formulate drug treatment programs for animals, create more targeted veterinary drug products, and make new contributions to the healthy development of animal husbandry.