Where is the root of depression?

First of all, let's talk about the physiological causes of depression.

At present, there are many theories about the physiological causes of depression, but they usually point to the disorder and imbalance of monoamine transmitters and serotonin transmitters. These neurotransmitters usually control people's happiness and happiness. For example, serotonin is actually serotonin produced when people fall in love. Once these neurotransmitters, or hormones, become less or out of balance due to brain problems, people will fall into sadness. This is the pathogenesis of depression.

Then solving it usually requires drug control. This disease can be cured clinically in principle, but its cause cannot be completely solved, so try to stay away from the behaviors or situations that may be induced by stimulation.

Apart from physical problems, I will talk about the psychological causes of depression separately.

In fact, there are many such studies. Since the 1920 s, there have been special psychologists to study. Psychoanalysis was the main school of psychology at that time. Psychoanalysis believes that the cause of depression is the reverse replacement of death instinct. Although, in the later period, psychologists made great changes to psychoanalysis, which was improved and overturned by Freud's disciples, and a new psychoanalysis with psychological motivation as the theme was formed, the theory of life and death instinct was still retained in the new theory, so the cause of depression did not change much.

Simply put, from the perspective of psychodynamics, depression is because people first have an impulse called death instinct, which generally represents the anger that people want to kill each other when they are hurt, and everyone will have it. Depression, on the other hand, is when people have this impulse, they are strongly resisted and obstructed by the outside world, their strong anger is suppressed, and their death instinct points to themselves, thus forming depression.

Because anger can also be interpreted as self-protection of fear. Therefore, this theory can also be interpreted as: after being strongly hurt, people form certain fears and think that many people may hurt themselves. Patients can't resist. In order to avoid being hurt, patients can only choose to hurt themselves to offset those possible injuries.

Simply put, after some kind of injury, there are far fewer people who support you than those who oppose you, so you are afraid and can only obey those who oppose you in the end. So why are people who are hurt by hateful spray and hooligans more likely to get depression?

The solution is naturally to find people who support and sympathize with you and defeat the rebels.

In addition to psychoanalysis, there is another theory called cognitive psychology, which holds that depression is caused by people's wrong cognition of objective things and can also be solved by changing cognition.

That's my answer. I hope I can help you.

Depression, which people avoid talking about, has existed since human beings. However, depression, which seems to be far away from us, is real. There are about 400 million people suffering from depression in the world, with the incidence rate of 6. 16% in Sweden, 4.45% in the United States and 3.02% in China, with an increasing trend year by year.

With the development of network information, nearly half of netizens now get some information about depression from gossip news of stars, but it is still far from the knowledge level. About 90% of friends don't know that people with depression may seriously lead to suicide.

This is a subject that can't be studied in three days and three nights. Here are some general examples to let you know some specific reasons:

The factors leading to depression are 1. Heredity: About 40%-70% patients have genetic tendency, and about 50% patients have a family history of depression;

2. Biochemical factors;

3. Neuroendocrine dysfunction;

4. Psychosocial environmental factors: unsatisfactory marriage, low economic income and major life events;

5. Personality factors: anxiety, tension, compulsion for perfection and impulsive sensitivity;

6. Unfortunate childhood experiences;

7. Physical illness;

8. Abuse and dependence of psychoactive substances.

Genetic factors show that genetic factors, such as family members with depression, have a higher risk of this disease, which may be caused by heredity. If you have financial strength or interest, you can go to the hospital to test your DNA, and you can know your gene sequence on the basis of modern science.

From the biochemical point of view, sublimation here mainly refers to the disorder of nerves in the brain. According to years of investigation and study, it is not difficult to find that 93.2% of patients with depression are determined by the disorder of secretion function.

Let's skip other social and environmental factors and talk about social and environmental factors. When people grow up from children to adults, they will encounter things that they can't accept, such as the death of their loved ones, failure in the college entrance examination, unemployment, and even betrayal of their loved ones.

All these will lead to depression, and pessimism, negative energy bursting, poor self-confidence, loss of control over life, excessive worry and so on will aggravate the severity of depression.

In short, depression is a high-incidence mental illness, and it is definitely not a "serious" or "rich disease". There is no difference between being poor and not being poor in the face of depression.

I hope more people can face up to depression, reduce misunderstandings about depression, reduce the harm to patients with depression, and don't let regrets happen again.

If it helps you, you can pay attention to' Stone Forest Psychology' ...

The causes of depression are composed of two aspects, on the one hand, genetic reasons, on the other hand, environmental and stress events. Of course, the cause of depression is related to heredity. The genetic contribution of depression is about 40%, that is to say, whether we will get depression in this life is 40% genetically determined. The remaining 60% is due to various environmental factors. What are the environmental factors? Mainly some major stress events, such as abuse, natural disasters or some emotional events, such as lovelorn, death of relatives, social isolation in childhood or adolescence, or excessive work pressure, are all environmental factors that will increase the incidence of depression.

The imbalance of serotonin in the brain is the most critical factor leading to depression. The various neurohormones in the brain are not the less the better, nor the more the better, so it is important to keep a balance between them. -TG2 protein, a kind of protein in the brain, is responsible for transforming serotonin into RAC 1 protein, and then promoting the synthesis of brain-derived nerve growth factor (promoting the development of cranial nerves and regulating neuronal plasticity). If people are in a chronic stress environment for a long time, such as long-term disharmony in marriage, long-term neglect of work, long-term absence of friends at school, social isolation, etc. The TG2 protein secreted by the brain will increase, which will reduce our ability to regulate emotions. Too high TG2 makes the concentration of serotonin in the brain too low, which affects the communication between neurons and leads to depression symptoms of "failure". The study of mice found that the increase of TG2 protein in the brain would lead to the atrophy of neurons and the decrease of TrkB molecular level, thus destroying the connection function between neurons. The effective connection between neurons is the physiological basis for maintaining normal cognitive and emotional activities of animals.

The causes of depression are introversion, lack of communication with others, great internal pressure, inability to release, and lack of understanding from others, which leads to long-term depression and depression over time.

Dopamine in the brain is far below the normal level.

What I see now is from two dimensions: one is genetic factor and the other is social factor.

1) Heredity: Some studies show that the heritability of major depression is about 37% through twin and non-twin experiments. So if one of your brothers and sisters suffers from depression, to a certain extent, your probability of suffering from depression is higher than that of other normal families. Not only depression, but also other mental diseases, such as schizophrenia, run in the family.

2) Social factors are mainly divided into life events and interpersonal communication. A interpersonal communication: it can also be said to be a social support system. This is actually a very important factor. The support of family members and the help of friends will greatly cushion the negative impact of stress events.

B Life events: In some studies, it shows that about 42% to 67% people reported that they had encountered an important life event before depression, such as losing a work friend or lover. These specific life events are also more likely to lead to depression. There are other factors, such as the economic situation of individual families, which may more easily lead to depression in some poorer families.

At the same time, on the issue of depression, there is a more important word called learned helplessness. If a person encounters setbacks and problems for a long time and can't get rid of them effectively, it is easy to have despair. In this person's cognition, he will think that he can't get rid of this problem and may fall into depression.

A theory similar to this is called despair theory: basically: ① think that there will be no good result. I don't think anything I can do can change this situation. So, I'm depressed. Really desperate.

Depression is a very complicated disease, the exact cause of which is not clear, but there are some factors that can lead to depression. Some people are depressed during serious illness, some people are depressed during major life changes, some people have a family history of depression, and some people are depressed for unknown reasons.

There are several main risk factors for depression:

Depression is a 5- hydroxytryptamine (also known as serotonin) deficiency. Other factors are external factors, which is a necessary condition for the diagnosis of depression. Not only depression, but also any mental illness must be diagnosed through physiological reasons to avoid confusion with normal psychological processes.

However, the current psychotherapy is mixed. If you say that you feel a little depressed, some psychologists will say that you have depression, and immediately prescribe medicine for you to be hospitalized without any examination at all. Some people are in a bad mood and never see a doctor, saying that they have depression. All these have led to the popularity of the word "depression" in public opinion. In fact, there are not so many.

Depression can happen to anyone, and it is a natural manifestation of conflict between people and the environment. For example, if you lose money in business, everyone will be depressed for a while. This has nothing to do with depression.

As we know, depression is a significant and persistent depression, accompanied by decreased sleep, decreased energy, decreased attention, decreased interest, social withdrawal, slow thinking, self-blame, low self-evaluation and pessimism. Depression is often accompanied by anxiety symptoms, and patients with severe depressive episodes may also have psychotic symptoms. So where is the root of depression? Is it our internal factor or the external factor of society?

In my opinion, there are internal and external causes, but more root causes should be the internal causes of depressed patients.

Many people will say that the root cause of depression is that patients are "small-minded" and "hard-headed", but it is not. Can not relax, narrow-minded people can have depression, but emotions can appear in any normal person, will not exist for a long time, will have a serious impact on a person's work and life. The symptoms of depression will be more serious and last longer, which will have a serious impact on people's work and life.

In fact, the root cause of depression should be the comprehensive effect of genetic factors, biological factors and social psychological factors. This is the conclusion of current medical research and the knowledge of medical circles all over the world. A single factor is not enough to cause the disease, and it must be depression caused by the superposition of many factors.

In life, depression is easily mistaken for depression, that is, depression as a disease attribute is often ignored. Because some patients with depression only pay attention to physical symptoms (fatigue, loss of appetite, pain, sexual dysfunction and so on. ), there are not a few people who are misdiagnosed and mistreated. For example, a girl with multiple depressive episodes was treated as a stomach disease by the hospital because of anorexia and vomiting, and the symptoms remained after the operation. Finally, she was diagnosed with depression.

In fact, due to the serious lack of people's cognition of depression, it not only leads to speculation and different opinions on the root causes of depression, but also makes many patients miss the opportunity of timely and correct treatment. In fact, if depression can be treated promptly and effectively, the curative effect will generally be very good. Almost all patients with depression will have obvious relief, and more than half will not recur in the future.

Depression is a chronic mental illness. Once found, scientific treatment should be carried out as soon as possible. I believe that people with depression will get better.

Depression is a serious global mental health disease. According to WHO statistics, the incidence of depression is about 3. 1%, and about1-200 million people worldwide suffer from depression. At present, the disease has ranked the fourth among 10 diseases in the world, and may become the main killer of human health in 2 1 century. Depression is a disease with extremely complicated pathogenesis. The research on its etiology is mainly discussed from the aspects of heredity, environment, psychosocial factors, biochemistry, neurotransmitters, endocrine, immunity and so on. Details are as follows:

I. Genetic research

Genetic research shows that depression is a highly inherited mental illness, and the risk of depression among relatives of depressed patients (especially first-degree relatives) is significantly higher than that of the general population.

Second, the study of neurotransmitters.

At present, it is generally believed that monoamine transmitter system is an important influencing factor to induce depression. Monoamine transmitter system mainly includes 5- hydroxytryptamine system, dopamine system and norepinephrine system. It is believed that monoamine transmitters in the brain, such as serotonin, play a key role in the occurrence, development and treatment of depression. In addition, monoaminergic nuclei in brain stem can also participate in depressive behavior, because serotonin and noradrenergic systems play a role in inhibiting autonomic activities.

Third, neurobiochemical factors.

It is found that the pathogenesis of depression may be related to many neurobiochemical factors, such as the imbalance of neuroactive steroids, the change of interaction between adenosine and its receptor, and the abnormal decrease of estrogen level.

Fourthly, the study of the neural immune system.

Neuroimmune system disorder is not only related to mental, psychological, personality, behavior, aging and other factors, but also closely related to the occurrence of various physical diseases. Some people think that most patients with depression have abnormal immune system function, which may be due to the increase of adrenocortical hormone caused by HPA axis hyperactivity, which leads to the suppression of immune function, or the change of monoamine transmitters, which affects immune function through corresponding receptors on immune cells.

Study on brain-derived neurotrophic factor (BDNF)

The level of BDNF in plasma of patients with depression is significantly lower than that of normal people, and antidepressant treatment can significantly improve the level of BDNF in their bodies. This result shows that the occurrence of depression may be related to the low level of BDNF.

A Social Psychological Study of Intransitive Verbs

Social psychological factors such as personality characteristics, family environment, stressful life events, social support and coping styles of different individuals play a key role in the occurrence, development and treatment of depression. The study on the correlation between personality and depression found that the occurrence and development of depression have a certain personality basis, and the probability of depression varies greatly among people with different personality traits, among which neuroticism and psychoticism are positively correlated with the occurrence and development of depression, while extraversion is negatively correlated with the occurrence and development of depression. In addition, the intimacy, contradiction, emotional communication, independence, entertainment, organization and control among family members have great influence on individual emotions, behaviors and interpersonal relationships. It is found that the family members of neurosis patients have low intimacy, many contradictions and conflicts, and less emotional expression. In addition, some studies have found that there is a certain relationship between depression and social support, which is characterized by more interpersonal relationships but less social support. In addition, stressful life events may be an important cause of depression, especially negative stressful life events, such as widowhood, death of relatives, divorce, unemployment and marital disharmony. At the same time, chronic psychological and social stimuli such as long-term poverty, chronic physical diseases, interpersonal disputes and family conflicts may also be important incentives for depression. It is found that there is a special relationship between the number of negative stress life events and coping, that is, when negative stress life events accumulate to a certain number, it will lead to depression. However, not all people who encounter stressful life events will suffer from depression. The study found that some patients with depression had no obvious stressful life events before the onset. It is generally believed that stressful life events play a "trigger" role in the occurrence and development of depression. The negative and immature coping style of individuals is an important factor leading to depression after stressful life events.

To sum up, depression is a common mental illness in clinic, and its pathogenic factors are very complicated. Most people think that it is caused by the interaction of biological, social and psychological factors and multiple mechanisms, but there is no unified conclusion at present.

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