Is nucleic acid test negative normal? Can nucleic acid test negative carry virus?

As we all know, nucleic acid detection is a widely used detection method at present. It can detect the virus in a few hours, which can prevent and control novel coronavirus well. Many people will do nucleic acid testing, especially those who go out to work. So is it normal to have a negative nucleic acid test? Let's take a closer look!

Is nucleic acid test negative normal? Negative nucleic acid test means normal.

Novel coronavirus is a newly discovered virus, and a negative nucleic acid test means that novel coronavirus has not been detected in the patient's respiratory tract sample or blood sample. Under normal circumstances, the nucleic acid test is conducted twice every other day or more. If both tests are negative, it means that the patient is not infected with novel coronavirus. For patients who have been infected, the test is negative after treatment, indicating that the patient has been cured.

If the nucleic acid test is negative, it means that the body is healthy. Usually pay more attention to rest, keep enough sleep and enhance immunity. Taking time out to do some aerobic exercise every day can effectively enhance your physical fitness, and you can also drink more warm water to promote the discharge of metabolites and pay attention to lower body hygiene.

Whether the nucleic acid test is negative or not carries the virus is generally not carried unless it is false negative.

Negative nucleic acid test cannot completely rule out the possibility of novel coronavirus infection. The detection rate of any virus nucleic acid detection can't be 100%, and false negatives are inevitable. At the same time, the detection rate may also be related to many factors such as the severity of the patient's condition, the development stage of the disease course, sample selection, laboratory testing conditions and so on. For the diagnosis of COVID-19, nucleic acid detection is still an indispensable means, and those who test positive can be confirmed as confirmed cases. However, the suspected cases with negative test still need isolation treatment and close observation in designated hospitals according to the diagnosis and treatment plan. For suspected cases isolated for 14 days, the nucleic acid test is negative again, and most of them can rule out novel coronavirus infection, but a few super communicators may be in a mild condition and in the stage of disease development, and the nucleic acid test will be negative.

The development of detection kit needs more than a dozen key chemical raw materials, such as enzymes and synthetic DNA. Different companies choose different raw material suppliers, so the enzyme activity and DNA purity will be different, which will affect the detection accuracy of nucleic acid detection reagents. However, in the research and development process of kit products, there may be deviations in raw material preparation, production process selection, R&D personnel capacity, technical means use and other aspects, and the accumulated errors will also lead to differences in the sensitivity of kit products. Irregular sampling process will also affect the subsequent separation and determination results, resulting in "false negative" test results. Taking the most commonly used and simple throat swab collection as an example, the low content of COVID-19 in pharynx may lead to missed detection.

Generally, it takes 1-2 days for nucleic acid detection to produce results. The latest kit can produce results within half an hour, but it is not clear whether it has been put into use in large quantities.

The detection time of coronavirus nucleic acid varies according to the kit used. Since the epidemic in novel coronavirus, many national departments have been developing novel coronavirus nucleic acid detection kits, and the current kits can produce results in about 2-3 hours at the earliest. Due to the extensive use of nucleic acid detection kits and the improvement of detection speed, the diagnosis speed of infected people in novel coronavirus is obviously accelerated.

The nucleic acid test results of infectious pneumonia in novel coronavirus can be obtained on the same day, and the results can be displayed directly because they are detected by nucleic acid reagents. At present, nucleic acid detection is a method to diagnose infectious pneumonia in novel coronavirus. When novel coronavirus nucleic acid is positive, isolation and unified treatment are needed, which can greatly avoid the spread of the virus. There is no specific treatment for infectious pneumonia in novel coronavirus, so personal protection should be strengthened to avoid virus infection.

Is the accuracy of nucleic acid detection high? Novel coronavirus nucleic acid detection is accurate, but there is a certain false negative rate. Generally, patients suspected of novel coronavirus infection can only be diagnosed after many tests. As long as novel coronavirus's nucleic acid test is positive, it is infected with novel coronavirus. If novel coronavirus's nucleic acid test is negative, this does not mean that novel coronavirus is not infected. We should check it more often. Some patients have to go through three or four examinations before they can be diagnosed. This is because if there are fewer viruses in the body and nucleic acid detection is not so sensitive, it will not be detected.

Although the result of nucleic acid test is accurate, it can't be confirmed by 100%, and it will be rechecked after the result is checked. If the virus is not detected, the infection cannot be ruled out. It is best to choose multiple tests, which can increase the accuracy of the inspection. During this period, you need to wear a mask in time and don't go to crowded places.