What are the chances of successful embryo transfer of IVF?

What are the chances of successful embryo transfer of IVF?

Do you know the chances of successful embryo transfer of IVF? The success rate of IVF transplantation is not 100%, so there are still many factors that affect the success rate of IVF. So what are the factors? Let me talk about the relevant factors.

What is the probability of successful embryo transfer of IVF? 1 Factors of successful embryo transfer.

1, embryo quality

With the continuous progress of medical science, we have the conditions to provide a good growth environment for embryos in advanced laboratories. Embryos will be cultured and developed in the laboratory for about 5 to 6 days, so that they can develop to the blastocyst stage. The use of blastocyst transfer will improve the pregnancy rate to a certain extent, because the embryos that survive and develop into blastocysts will be healthier and stronger. At the same time, it also means that doctors will have a greater chance of success in single embryo transfer.

Different from domestic IVF, domestic IVF is limited by laboratory, technology and policy, and embryos are generally cultured until the third day before transplantation. Due to the limited technology and medical level in the laboratory, it is difficult for embryos to keep fresh and energetic after the third day of laboratory culture. In this case, only the embryos on the third day can be transferred, which leads to low pregnancy success rate and poor quality of the remaining embryos, and it is difficult to preserve them for future embryo transfer through cryopreservation, which increases the risk and often brings the pain of abortion.

With the high development of scientific research technology in the United States and the guarantee of high-quality laboratories, embryo culture can develop to the blastocyst stage on the sixth day. Using blastocysts for transplantation will greatly improve the success rate of IVF conception.

2. Embryo freezing technology

In the past, due to technical limitations, freezing embryos was very risky, and it was impossible to guarantee whether embryos could survive during freezing or thawing. The main reason is that the traditional slow freezing technology is backward, and the cells in the embryo are easily destroyed by ice crystals formed by water in the cells, which leads to the decline of embryo quality and the failure of transplantation.

However, the advent of a breakthrough freezing technology has greatly promoted the development of IVF technology. This freezing technology is called vitrification, which can be said to be a "flash freezing" process, which can quickly cool the embryo to a frozen state within a few seconds.

In addition, scientists have also developed methods to protect cells with special media, such as using cryoprotectants to successfully freeze embryonic cells.

With the development of technology, the freezing and thawing of eggs and embryos is no longer a problem. The survival rate of thawed embryos has reached 99%, and the success rate of conception after thawing is also very high.

What is the probability of successful embryo transfer of IVF? 2 1. Count the number of eggs obtained from ovarian storage in one cycle.

The simplest formula to calculate the success rate of IVF is to evaluate the number of eggs. Usually, the success rate of an egg is around 5%, which can only be estimated. With the increase of age, the quality of female eggs is declining, but the general trend is right.

The more follicles there are at the beginning of menstruation, the higher the success rate will be. In addition to the small number of eggs obtained by micro-stimulation program, the number of eggs obtained by women with normal ovarian function is generally roughly equal to the number of follicles in the early menstrual period.

Therefore, the microstimulation program with the goal of less than 4 eggs is often called placebo program. According to statistics, the single success rate of microstimulation is between 3% and 25%. Especially for women over 40 years old, the single-cycle success rate is about 3%-5%.

Step 2 estimate the number of embryos

After knowing the number of eggs obtained, the next step is to estimate the expected number of future embryos. On the premise of normal semen, those with high sperm deformity rate and high sperm breakage rate can trust me privately.

American FGH Company published such a set of data. Statistics on a large number of people:

(1) For women under 35 years old (5: 1), usually six eggs can form five mature eggs, four can be fertilized, and finally two blastocysts will be formed. After screening by PGS, there is a 60% probability of passing, and finally 1 and two completely healthy blastocysts will be harvested.

(2) Women aged 39-40 (65,438+00: 65,438+0), usually 65,438+00 eggs can form 8 mature eggs, 6 can be fertilized, and finally 3 blastocysts will be formed. After screening by PGS, there is a 30% chance of passing, and finally 0 or 9 blastocysts with completely healthy chromosomes will be harvested.

(2) Women aged 42-43 (18: 1), usually 18 eggs can form 14 mature eggs in MII stage, and 10 eggs can be fertilized, and finally five blastocysts will be formed. After PGS screening, there is a 20% chance to pass. Finally,

According to this ratio, we get the following table. Egg donors and people of all ages usually need the number of eggs to obtain a blastocyst.

Step 3 Estimate the success rate

The last step is coming soon, which involves a very important interference factor-uterus.

If you have a history of live birth, and the time is not long, you can basically check out the uterine factors.

Then the live birth rate of each blastocyst passed the third generation test is about 40-50%, generally there are two embryos, and the success rate is about 80%.

Therefore, women who are not disturbed by the uterus have a success rate of 80%. How many times do they have to make test tubes at least?

For those with disturbed uterus, we will analyze various situations in detail in the next issue. Basically, they are mainly discounted, and the number of cycles multiplied by 2 may be higher.