Effects and side effects of atropine

Anticholinergic drugs with pharmacological action of blocking M choline receptor can relieve the spasm of smooth muscle (including relieving vasospasm and improving microvascular circulation); Inhibit gland secretion; Relieve the inhibition of vagus nerve on the heart and accelerate the heartbeat; Dilate the pupil and increase the intraocular pressure; Excite the respiratory center. Adverse reactions (1) Common ones are constipation, decreased sweating, dry mouth, nose and throat, blurred vision, flushing of skin, dysuria (especially in elderly patients) and dry mouth (especially in men). (2) Rare cases are: elevated intraocular pressure, allergic skin rash or herpes. (3) Over-dosage is characterized by clumsy and unstable movements, unconsciousness, convulsions, hallucinations, delirium (more common in elderly patients), shortness of breath and difficulty, slurred speech, abnormal rapid heartbeat, excitability, nervousness, restlessness (more common in children) and so on. Dry mouth, dizziness, flushing on the face or skin, tachycardia, delirium or delirium. Extremely large doses can cause convulsions, excitement and blurred vision. Intravenous injection may cause cardiac arrest. Subcutaneous injection may cause drug eruption. Arrhythmia is common in adults with atrioventricular disjunction, while in children it is atrial arrhythmia. Some patients have tachycardia or even ventricular fibrillation, which may be caused by the dosage exceeding 1mg, but sometimes the dosage of .5mg can also cause the above complications. This medicine can increase the breathing speed and depth, which may be a reaction to the increase of dead space after bronchiectasis. Recently, some reports have pointed out that atropine can cause memory insufficiency. It is reported that 57 patients with femoral neck fracture were given atropine before anesthesia and suffered from mental confusion after operation. It has been reported that the application of atropine-containing patches can also cause central nervous system reactions, such as visual disturbances and hallucinations. The most common allergic reactions are contact dermatitis and conjunctivitis. When dripping eyes, it sometimes causes irritating conjunctivitis. When in use, the lacrimal sac should be compressed, especially for children. If absorbed through nasolacrimal duct, it may cause systemic symptoms. The main manifestations are dry mouth, decreased saliva secretion, anhidrosis, skin flushing, dizziness, increased heart rate, irritability, blurred vision and shyness. The skin is dry and hot, and rash may appear, especially on the face, neck and upper trunk, which may be desquamated. When atropine is used to treat ametropia in children, there may be mild but amazing toxic reactions. You can go to Baidu's encyclopedia for details.