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Why can't I drink after eating cephalosporin?
After alcohol enters the body, it is firstly oxidized into acetaldehyde under the action of "alcohol dehydrogenase" in liver cells, and acetaldehyde is oxidized into acetic acid and acetaldehyde enzyme A in liver cell mitochondria under the action of acetaldehyde dehydrogenase, and acetic acid is further metabolized into carbon dioxide and water, which inhibits the activity of acetaldehyde dehydrogenase in liver cell mitochondria. Because some drugs contain methyl tetrazole side chains in their chemical structures, acetaldehyde cannot be further oxidized and metabolized after being produced, which leads to the accumulation of acetaldehyde in the body and the occurrence of disulfiram-like reaction.
In addition to cephalosporins, other drugs can also cause disulfiram-like reactions: imidazole drugs such as metronidazole and ornidazole; Other antibiotics such as furazolidone, ketoconazole, compound sulfamethoxazole, isoniazid, etc.
Sulfonylurea hypoglycemic agents, such as gliclazide and glipizide; Other drugs such as warfarin, tolasulin, etc.
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