Take progesterone leucorrhea much?

Progesterone is a natural progestin secreted by corpus luteum of ovary, which has significant morphological effect on endometrium stimulated by estrogen in vivo and is necessary to maintain pregnancy. Its pharmacological effects are as follows: ① In the late menstrual cycle, glands in the uterine mucosa grow, the uterus is congested, and the endometrium thickens, so as to prepare for the implantation of fertilized eggs. After implantation, the fertilized egg will produce placenta, which will reduce the excitability of pregnant uterus, inhibit its activity and make the fetus grow safely. (2) Under the same effect as estrogen * * *, promote the full development of breasts and prepare for milk production. ③ The cervix is closed, mucus is reduced and thickened, and sperm is difficult to penetrate; At high dose, hypothalamic negative feedback inhibits the secretion of pituitary gonadotropin, leading to ovulation inhibition. After oral administration of 1 ~ 3 hours, the blood concentration of this product reaches the peak, and it is inactivated due to rapid metabolism, so it is generally administered by injection, but sublingual administration or vaginal and rectal administration is also effective. After rapid absorption by vaginal mucosa, the blood drug concentration reached its peak after 2 ~ 6 hours. Clinically, it is mainly used for habitual abortion, dysmenorrhea, menorrhagia or metrorrhagia, amenorrhea, etc. Oral large doses are also used for diseases caused by progesterone deficiency, such as premenstrual syndrome, menstrual disorder caused by ovulation cessation, benign breast diseases, premenopausal and menopause. Vaginal administration can replace oral administration, especially for patients with liver disease.

Injection: each tablet 10 mg (1 ml); 20 mg (1 ml). Capsule: per capsule 100 mg.

Compound progesterone injection: light yellow clear oily liquid, 65438±0ml each, containing 20mg progesterone and 20mg estradiol benzoate. The usage is the same as progesterone, but the effect is better. Intramuscular injection 1ml every day for 2 ~ 4 days.

Trishormone injection: light yellow clear oily liquid, each containing 1ml, progesterone 12.5mg, testosterone propionate 25mg, estradiol benzoate10.5 mg. Its usage is similar to that of compound progesterone injection, and it is mainly used for irregular menstruation, but the amount of bleeding is less after withdrawal. It is also used for menopausal syndrome and milk withdrawal. Muscle retention 1 time for 3 ~ 5 times every day or every other day 1ml.

Intramuscular injection, 1 time 10 ~ 20 mg.

(1) habitual abortion: intramuscular injection 1 time 10 ~ 20mg, 1 time per day or 2 ~ 3 times per week until the fourth month of pregnancy.

(2) Dysmenorrhea: inject 5 ~ 10 mg every day 6 ~ 8 days before menstruation, and the course of treatment can be repeated several times. Can be used with estrogen for dysmenorrhea caused by uterine hypoplasia.

(3) Hypermenorrhea and metrorrhagia: intramuscular injection of 10 ~ 20 mg every day for 5 ~ 7 days, which can be repeated for 3 ~ 4 courses with an interval of 15 ~ 20 days.

(4) Amenorrhea: After 2-3 weeks of estrogen administration, give this product 3-5 mg per day immediately, with 6-8 days as a course of treatment. The total dose should not exceed 300-350 mg, and the course of treatment can be repeated 2-3 times.

Oral or vaginal administration: 1 time 100mg, morning and evening 1 time (2 hours before going to bed), and each cycle lasts 10 day (usually 17 ~ 26 days).

Precautions: dizziness, headache, nausea, depression, breast pain, etc. Long-term application can cause endometrial atrophy, decreased menstrual flow, and prone to vaginal mold infection. Patients with liver disease cannot take it orally.