What causes Alzheimer's disease?

At present, the etiology of Alzheimer's disease is not very clear, but there are many known causes of Alzheimer's disease. 1. Brain degenerative diseases: There are many kinds of dementia caused by brain degenerative diseases, among which Alzheimer's disease dementia is the most common, and Alzheimer's Harmo disease is also called Alzheimer's Harmo disease. Its onset is slow and it is progressive dementia. In addition, there are Pick's disease, Dington's dementia, progressive supranuclear paralysis, Parkinson's dementia and so on. The latter dementia is rare. 2. Cerebrovascular diseases: The most common type is multiple cerebral infarction dementia, which is caused by a series of repeated mild cerebral ischemic attacks and repeated accumulation leading to substantial cerebral infarction. In addition, there are subcortical vascular dementia and acute paroxysmal cerebrovascular dementia, which can rapidly develop into dementia after a series of strokes caused by cerebral hemorrhage and cerebral embolism, and a few can also be caused by large-scale cerebral infarction. In short, cerebrovascular disease is also a common cause of Alzheimer's disease. 3. Genetic factors: Many studies at home and abroad have proved that the offspring of Alzheimer's patients have more chances to suffer from this disease. But its genetic mode is still unclear. Some people think it is dominant inheritance; Others think it is recessive genetic inheritance; Some people think that it is polygenic autosomal recessive inheritance, and the genetic effect can be restricted by environmental factors and genetic factor mutations, thus interrupting its genetic effect. There are also some studies that Alzheimer's disease is a non-hereditary disease, such as vascular dementia, which is not directly related to heredity. 4. Endocrine diseases: such as hypothyroidism and hypothyroidism may cause dementia. 5. Nutritional and metabolic disorders: Dementia is caused by the damage of brain tissue and its function caused by nutritional and metabolic disorders. For example, encephalopathy caused by various organs, such as renal encephalopathy, is cerebral ischemia and hypoxia caused by chronic renal failure and uremia, which can lead to dementia; Other diseases, such as hepatic encephalopathy and pulmonary encephalopathy, can cause dementia. Severe nutritional deficiency, such as vitamin B 1, B 12, niacin and folic acid deficiency, can lead to dementia. Both diabetes and hyperlipidemia can cause atherosclerosis of large and middle arteries, thickening of basement membrane of small blood vessels and microvessels, cerebral infarction and cerebral hemorrhage, leading to vascular dementia. 6. Tumors: Metabolic disorders caused by malignant tumors can lead to dementia, and brain tumors can also directly damage brain tissue and lead to dementia. 7. Poisoning by drugs and other substances: Alzheimer's disease caused by alcoholism and chronic sperm poisoning is not uncommon, but it has not been recognized. Long-term exposure to aluminum, mercury, gold, silver, arsenic, lead, etc. Poor protection can lead to dementia after chronic poisoning. Carbon monoxide poisoning is also a common cause of acute dementia. 8. AIDS: AIDS is one of the causes of senile dementia. At present, it is known that the elderly can have progressive dementia in the early stage of AIDS, and it has been confirmed that the central nervous system can be directly infected with human immunodeficiency virus (HIV). 9. Syphilis: Treponema pallidum can invade the brain, produce mental and neurological symptoms, and finally lead to paralysis, mental retardation and personality change, which is called paralytic dementia. 10. Others: brain trauma, persistent seizures and normal pressure hydrocephalus can all cause senile dementia. In addition, the long-term depression, loneliness, widowhood, illiteracy, low language level and lack of physical and mental exercise of the elderly can also accelerate the brain aging process and induce Alzheimer's disease.