Mitochondrial joke

If anti-aging is compared to learning, skin care products containing hyaluronic acid are like counseling books. It is certainly useful to learn the knowledge in the book, but only if you can read it. Hyaluronic acid can help to moisturize the skin, but the hyaluronic acid molecules added in skin care products are rarely absorbed by the skin, just like buying a lot of books without reading a few words, the academic performance will not be greatly improved.

Caffeine-containing skin care products can promote facial blood circulation and improve facial edema and dark circles under blood vessels. But it's like your parents driving you to and from school, saving you time on the road and preventing you from running and playing on the way after school. And how efficient you are in your later study depends on yourself.

Skin care products containing vitamin A alcohol can stimulate collagen production and increase skin elasticity, but it is inevitable that it is highly irritating and needs to establish tolerance, especially for sensitive skin. Just like a very strict teacher, holding a pointer behind him to urge you to study, although it will help your academic performance, this process is really painful and really not suitable for some students.

It's not that these ingredients are not good, but how can we learn efficiently? No doubt, of course, you are actively studying!

In the same way, how can the anti-aging effect be good?

Of course, cells take the initiative to resist aging!

How do cells actively resist aging?

This cannot but mention the mysterious power of the anti-aging Sirtuins protein family!

Sirtuins(SIRT) is a deacetylase widely distributed in cells. Simply put, it is a large family of longevity proteins composed of a group of protein.

There are seven recognized members in this family: SIRT 1-SIRT7. They are widely distributed in cells and have many functions. In 2005, Michishita and others found that SIRT 1, SIRT6 and SIRT7 were distributed in different parts of the nucleus, SIRT 1 was mainly distributed in nucleosomes, SIRT7 mainly existed in nucleoli, SIRT2 usually existed in cytoplasm, while SIRT3, SIRT4 and SIRT5 mostly existed in mitochondria, among which SIRT3 mainly distributed in the inner membrane of mitochondria, and Sirt7 mainly existed in mitochondria.

Sirtuins protein family is widely distributed in cells and participates in regulating cell differentiation and apoptosis, metabolism and genome stability. Sirtuins is a NAD+-dependent histone deacetylase, so it can change the activity and stability of protein through lysine deacetylation, thus regulating the aging process.

In particular, three anti-aging experts SIRT 1, SIRT3 and SIRT6 were activated, which greatly enhanced the vitality of cells, activated the anti-aging potential of cells, and enabled cells to actively resist aging and oxidation, thus achieving more efficient anti-aging.

Let's introduce the three anti-aging masters of this family-

Living up to the mission of being the boss of the family is the research focus of anti-aging application at present.

SIRT 1 can protect cells and prevent them from aging. It can maintain the normal cell cycle of fibroblasts and maintain sufficient collagen in dermis. If the fibroblasts in the skin are metabolically disordered and aged, they will not produce collagen fibers normally, and the skin will be prone to wrinkles, reduce elasticity and become slack and droopy.

SIRT3 is a potential family member. Its main function is to maintain mitochondrial function and provide energy for cells stably, thus delaying cell apoptosis and prolonging cell life.

In addition, SIRT3 can activate autophagy and prevent the accumulation of senile plaque or lipofuscin in cells, thus leading to chloasma, senile plaque and skin aging.

SIRT6 can also protect cells, especially prevent ultraviolet rays from damaging cell DNA. SIRT6 is involved in repairing DNA damage, stabilizing genome, preventing cell aging and prolonging cell life.

Oxidative and stress damage will promote cell aging, which will lead to systemic aging. Therefore, Sirtuins protein family and other factors with multiple intracellular functions can sense the damage and protect the cells, help to improve the cell survival rate and improve cell aging, and maintain the cells at a more dynamic level, thus helping us to become the youngest offspring of GAI.

So how can we make the Sirtuins protein family "work"?

This is about catalysts.

Studies have shown that resveratrol, SRT2 104 and NMN can effectively activate Sirtuins protein, among which resveratrol and NMN have attracted much attention. (Related article: Firer than the meta-universe? Is NMN a myth or a joke)

Adding resveratrol, the activator of SIRT 1, before ultraviolet irradiation can protect fibroblasts in the skin, prevent the degradation of elastic fibers, and promote the regeneration of collagen, thus preventing the skin elasticity from decreasing and wrinkles. It can also prevent H2O2-induced apoptosis and inhibit cell aging. In other words, resveratrol not only can prevent photoaging, but also has great potential in improving cell aging. In addition, it can induce autophagy, regulate the normal metabolism of cells and inhibit the activity of tyrosinase in melanocytes.

Resveratrol is high in grapes, mulberries and blueberries (not anthocyanins, not to be confused). In addition, resveratrol is added to some skin care products, which has anti-aging effect together with other ingredients. You can look for skin care products with related ingredients.