What are the preventive measures for drug mixing and batch mixing in drug production system?

Measures to prevent mixed batch, confusion and pollution in GMP standard of Shennong Medical Forum are as follows:

(1) Producing different kinds of drugs in isolated areas;

(2) adopt phased production mode;

(three) set up the necessary air lock room and exhaust room; There should be pressure difference control in areas with different air cleanliness levels;

(4) The risk of pollution caused by untreated or improperly treated air re-entering the production area should be reduced;

(5) In the production area prone to cross-contamination, operators should wear special protective clothing for this area;

(six) the use of verified or known effective cleaning and decontamination procedures to clean the equipment; When necessary, the residue on the surface of equipment in direct contact with materials shall be detected;

(seven) the production of closed system;

(eight) the air inlet of the drying equipment should have an air filter, and the air outlet should have a device to prevent air from flowing backwards;

(nine) in the process of production and cleaning, should avoid the use of fragile, easy to fall off and moldy appliances; When using the screen, there should be measures to prevent pollution caused by screen damage;

(10) The preparation, filtration, filling and sterilization of liquid preparations shall be completed within the specified time;

(1 1) Semi-solid preparations such as ointments, creams, gels, and intermediate products of suppositories shall specify the storage period and storage conditions.