What are the main symptoms of Parkinson's disease?

Parkinson's disease, also known as paralysis agitans, is a common senile neurodegenerative disease with characteristic motor symptoms, including static tremor, bradykinesia, myotonia and postural balance disorder. It will also be accompanied by non-motor symptoms, including constipation, olfactory disorder, sleep disorder and autonomic dysfunction, that is, mental cognitive disorder.

The symptoms of Parkinson's disease vary from person to person, and the most obvious symptoms are static tremor, bradykinesia and myotonia. Postural balance disorder occurs in patients in the middle and late stage, accompanied by non-motor symptoms before and after the onset, including constipation, olfactory disorder, sleep disorder and autonomic nerve dysfunction, that is, mental cognitive disorder. In addition, some patients have mental disorders, and about 50% patients are accompanied by depression. Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and elderly people, which is characterized by the loss of dopaminergic neurons in substantia nigra striatum and Lewy bodies. It is common in people over the age of 60, but it occasionally appears in young people in their twenties. The main clinical symptoms are tremor, myotonia, bradykinesia, loss of posture reflex and abnormal balance. , the specific performance is the following symptoms:

1. Tremor: Typical patients show static tremor, mostly originating from the distal end of one upper limb. It is characterized by slow, moderate or thick tremor, which is aggravated when patients are nervous, excited, tired and anxious, and disappears after falling asleep;

2, myotonia: can appear in the early stage of the disease, mainly affecting the muscles of the trunk and proximal limbs. When the patient moves passively, the joint resistance increases and the limb can appear gear-like rigidity;

3, slow movement: spontaneous movement is reduced, the movement is slow and clumsy, such as lack of facial expression and blinking movement, similar to mask face. When walking, the upper limb swing decreases or disappears, writing becomes smaller and smaller, gait is flustered, speech is too slow, and swallowing is difficult;

4, posture reflex loss and abnormal balance: easy to fall, or even stand independently. When I changed from standing position to sitting position, my whole body fell into the chair. When the patient is in an unstable posture with the head forward and the trunk forward or backward, it is difficult to keep upright and easy to fall;

5. Other symptoms: depression, anxiety, depression, dementia, pain, hypoesthesia, sleep disorder, cognitive disorder, constipation, slow urination, postural hypotension, blepharospasm, etc. Patients with advanced stage may even have hallucinations.