What do you mean by high risk of Down's screening? What should I do?

The incidence of Down syndrome is not directly related to race and living standard. It is estimated that one in every 660 newborns suffers from Down syndrome, making it the most common chromosomal variation. Older primiparas increase the risk of Down syndrome in infants. The prevalence rate of 20-24 years old is11250, 35 years old is 1/400, 40 years old is1/06, and 45 years old is1/30,400. The reason is that with the increase of maternal age, the phenomenon of chromosome non-separation will increase during egg formation. On the other hand, however, about 80% babies with syndrome are born to mothers under 35. This is related to the high pregnancy rate of women under 35.

In addition, there are cases where the extra chromosomes come from the father, and the ratio of paternal cause to maternal cause is 1: 4. Families with potentially high risk of illness are usually advised to have genetic counseling and genetic testing, such as "amniotic fluid diagnosis".

Compared with children who are not sick, children with Down syndrome are at a direct disadvantage. It is generally believed that sick children are mentally retarded, their IQ rarely exceeds 60, and their brains are usually too small and light. The cerebellum, brain stem and anterior gyrus are surprisingly small. Education level will be limited by diseases and disabilities, such as recurrent infectious diseases, heart disease, amblyopia and hearing impairment. Other physiological features caused by diseases include distorted facial features such as wrinkles in apes, and some patients with Down syndrome will suffer from depression after puberty due to stress. But on the whole, there is a cheerful trend. After the age of 40, the incidence of Alzheimer's Harmo's disease is high, and it is prone to memory loss, persistent low cognitive ability, personality change and other symptoms.