My wife always doubts my relationship with my anonymous colleague. What should I do?

Personally, I think you should have a good talk with your wife and let her know that your job is not easy, that you need help from others, and that you won't have anything to do with other female colleagues, so that she can rest assured.

Furthermore, see if your own behavior worries your wife. The reason why your wife did this was to see or hear something. You should let your own behavior reassure your wife.

Besides, doesn't your wife do anything? Take care of the children at home every day, so that she will have more time and more ideas, such as: you came back late, your attitude towards her is not good, and so on. She feels confused every day. You must sit down and have a good talk with your wife and clarify your point of view. Let her know that it is not easy for you to work, it is not easy to make a living, and so on. Let her know you better, and she will understand and understand you!