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What should I pay attention to when donating hematopoietic stem cells?
What age is suitable for healthy people to donate hematopoietic stem cells?
/kloc-healthy people aged 0/8-45 can register as volunteers to donate hematopoietic stem cells, and/kloc-healthy people aged 0/8-55 can collect hematopoietic stem cells.
Why do healthy people aged 45-55 no longer accept registration?
The best age for collecting hematopoietic stem cells is 18-55 years old, and it will take some time for donors to find suitable patients after registration. In order to make full use of the limited testing funds, the registration age should not exceed 45 years old.
Health standards for voluntary donors of hematopoietic stem cells?
Anyone who is 18-55 years old, healthy and passes the following blood tests can become a hematopoietic stem cell donor.
Alanine aminotransferase 40 unit
Hepatitis B virus surface antigen: negative
Hepatitis C virus antibody: negative
HIV antibody: negative
Syphilis test: negative
How to join the database of hematopoietic stem cell donors in China and become a volunteer to donate hematopoietic stem cells?
If you are a school-age child, healthy and willing to donate hematopoietic stem cells, you can contact the hotline of the local Red Cross to register, fill in the voluntary donation book and related forms, and draw 5 ml of blood. The tissue matching laboratory will test your blood for HLA typing, and input all your related information into the computer database of China Hematopoietic Stem Cell Donor Database, so that patients who are eager for transplantation can find a match, and you will become an honorable volunteer to donate hematopoietic stem cells.
How do you know that you have become a volunteer to donate hematopoietic stem cells?
China Hematopoietic Stem Cell Donor Database: Donor service agencies located all over the country will inform you that you are accepted as a volunteer to donate hematopoietic stem cells and keep in touch with you frequently.
Is there any subsidy for donation registration and donation of hematopoietic stem cells?
Donating hematopoietic stem cells is a dedication of love and a good deed to save people. Subsidies are generally not advocated.
Will volunteers donate hematopoietic stem cells immediately after registration?
After registration, we should first arrange to take 5 ml blood for HLA typing test, and save the data in the database of hematopoietic stem cell donors in China for future reference. When a patient needs hematopoietic stem cell transplantation, the transplantation center will send the HLA typing data of the patient to the database. If the retrieval results show that only your HLA matches the patient, the provincial management center will inform you to make preparations for donation. This process may be short, or it may take several years. And most volunteers may not have the opportunity to donate.
What problems should be paid attention to as volunteers who donate hematopoietic stem cells?
When the telephone number and address of you or your contact person change, I hope to inform the registration department in time so as to find you quickly when necessary, so that the patient's illness can be treated in time and ensure that you realize your desire to save lives.
Can I change my decision to donate hematopoietic stem cells at any time?
The registration and donation of hematopoietic stem cells are based on voluntariness. After registration, the database will reconfirm your voluntariness. Testing your HLA database will cost some money. In order to save money, if you propose to terminate the donation, please think carefully. However, before transplantation, especially after signing the donation consent, the donation decision cannot be cancelled, because at this time, the patient must undergo large doses of radiotherapy and chemotherapy to prepare for transplantation, and at this time, the patient has lost his hematopoietic capacity. In the meantime, if the donation is stopped, it will be too late to find a match temporarily, and the patient will be in danger.
Why do donors have to fill in the consent form and donor registration form when registering the database of hematopoietic stem cell donors in China?
It is a noble act of dedication to join the database of hematopoietic stem cell donors in China and become a volunteer to donate hematopoietic stem cells. When necessary, donors will donate hematopoietic stem cells for patients free of charge. Therefore, the donor database of hematopoietic stem cells in China must obtain the written commitment of the donor, and know the exact mailing address and contact information of the donor through the registration form.
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Brief Introduction of China Hematopoietic Stem Cell Donor Database
China Hematopoietic Stem Cell Donor Database, also known as "China Bone Marrow Bank", was formerly known as "China unrelated bone marrow transplant donor database" approved by the Ministry of Health 1992. In February, 2000 1 and1,the Central Organizing Committee approved the establishment of the China Hematopoietic Stem Cell Donor Database Management Center (hereinafter referred to as the "database") to uniformly manage and standardize the publicity, organization, mobilization, HLA typing of voluntary donors, finding suitable hematopoietic stem cell donors and providing transplant treatment services for patients.
The construction of "database" is the need of human civilization and medical cause. Hematopoietic stem cell transplantation can be used to treat leukemia, acute radiation sickness, severe aplastic anemia, severe thalassemia, severe immune diseases and low immune function after radiotherapy and chemotherapy for cancer. Nearly one million patients in China need hematopoietic stem cell transplantation every year, and there are only 40 thousand new leukemia patients every year. The key to the success of hematopoietic stem cell transplantation is that the HLA typing of patients and donors must be consistent. The coincidence rate between identical twins is 100%, and that between siblings with blood relationship is 25%. At present, most teenagers are only children, so it is difficult to find a suitable compatriot donor after illness. To carry out hematopoietic stem cell transplantation, we can only rely on unrelated voluntary donors to provide matched hematopoietic stem cells, but the unrelated HLA matching rate is about1/400-110000. According to the actual situation in China, a "database" with more than 300,000 people should be built as soon as possible to meet the needs of clinical hematopoietic stem cell transplantation for leukemia patients.
China Red Cross Society is a social relief group engaged in humanitarian work. Building a database of hematopoietic stem cell donors in China is a special task entrusted by the government to the China Red Cross. It is a new service field of the Red Cross's humanitarian relief work, and it is also a practical and good thing that the Red Cross has done for the broad masses of the people by practicing Theory of Three Represents. In the past two years, the "database" has been strongly supported and valued by relevant government departments and all walks of life. At present, China has established 24 provincial sub-databases, 24 HLA designated tissue matching laboratories and 1 quality control laboratories. By the end of August 2003, more than 60,000 pieces of leukocyte antigen typing data that can be used to search patients have been accepted and searched for more than 3,000 times. Among them, nearly 300 volunteers' data are consistent with patients' leukocyte antigen typing, and more than 50 leukemia patients have been provided with hematopoietic stem cells for transplantation.
Establishing "database" is a systematic social assistance project. It is hoped that all sectors of society will continue to care for and support the construction of the "database" so as to save more leukemia patients, make the humanitarian purpose of the China Red Cross Society to protect people's lives and health and promote the cause of peace and progress widely spread, and make the spirit of humanity, fraternity and dedication of the China Red Cross Society carry forward.
How to register for storage: donation registration is actually very simple. When donating blood in a blood donation vehicle, you can collect blood samples and fill in the registration form, or you can take samples in collective blood collection activities.
The Process of Joining China Hematopoietic Stem Cell Donor Database
Please see this post for the process of donation: the process of donating hematopoietic stem cells after successful matching.
Cost: Volunteers don't have to bear any expenses during the whole process of warehousing and final donation. Of course, they can also donate testing fees if they want.
Do you have to donate blood to donate hematopoietic stem cells?
Personally, I understand that in order to prevent volunteers from choosing to refuse out of fear after successful matching, they generally need to have the experience of donating blood for free before they can register for storage, at least there will be no too much fear when inserting needles and drawing blood. Moreover, citizens have the obligation to donate blood for free, and blood donation is not an exaggeration.
Do I need my family's signature to donate bone marrow? If volunteers are identified, will the obstruction of family members affect the donation? It is best to get the consent of your family when you put it in storage, so as to avoid family obstruction or even family conflicts after successful matching. Of course, the consent of the family is not necessary. If the volunteers are confirmed, of course, it will not affect the donation, but it will affect their family relationship. So it's best to ask for good advice before. And do a good job in publicity.
Donate bone marrow and hematopoietic stem cells
I used to donate bone marrow, but now I donate hematopoietic stem cells. In fact, they are all collected hematopoietic stem cells, originally extracted from bone marrow blood and rich in hematopoietic stem cells, so they were originally called donating bone marrow. Hematopoietic stem cells are directly collected from peripheral blood, and the process is the same as donating blood component. Of course, it is necessary to mobilize a large number of hematopoietic stem cells existing in bone marrow into peripheral blood first. Therefore, the purpose of donating hematopoietic stem cells now is to distinguish it from the past and avoid misleading.
How do you know if you have entered the library?
Recently, many netizens have not received the notice of warehousing after collecting 5ml blood samples, and it is impossible to determine whether they have been warehousing. The answer to this question is this: Generally speaking, you are not informed that there is a problem with the blood sample after sampling, which means that it has been put into storage.
As for certificates, many sub-databases have been issued, but they are not perfect, and not all of them have been received. For example, if a blood donation vehicle is registered and put into storage, do you need the staff of the branch library to issue a certificate on the vehicle or the blood collection staff to issue it? None of this has been solved. Therefore, many of them were not registered in the blood donation car, but only distributed a part in a collective collection. There is also a collection place that is not where the branch is located, and there is no corresponding certificate in the local area, so it is not issued. These have yet to be solved.
How long can I donate blood without compensation? Six months.
Mobilize agents:
A few days before donating hematopoietic stem cells, a granulocyte colony stimulating factor will be given to promote the massive growth of hematopoietic stem cells and release them into peripheral blood. Application of granulocyte colony stimulating factor in hematopoietic stem cell donors before operation. Some people worry that there may be complications. See the following explanation:
The full name of this drug is recombinant human granulocyte colony stimulating factor injection (rhG-CSF), which is produced by gene recombination technology. It can selectively act on granulocyte hematopoietic progenitor cells, promote their proliferation and differentiation, and increase the number and function of neutrophils in peripheral blood. It exists in every normal person and is one of the main cytokines that regulate the hematopoiesis of bone marrow granulocytes.
The drug has been used in clinic for more than ten years, and its effectiveness and safety have been fully verified. After 24 hours of application in healthy adults, its concentration in urine has dropped below the detection limit. After several days of continuous administration, the serum drug concentration was monitored and no accumulation was found.
In the animal experiment of drugs, mice were injected with nearly 1000 times the clinical dose at one time, and no acute poisoning reaction was found. Long-term large-scale application (4 ~ 13 weeks) can increase the weight of ALP and spleen. But it will recover after stopping the drug.
The main adverse reactions reported in its clinical application are as follows: fever (1.3%); Bone pain and low back pain (1.2%); Abnormal liver function (0.5%); Rash (0.3%) and so on. There are few allergic reactions (incidence
Patients with aplastic anemia and congenital neutropenia may turn into myelodysplastic syndrome (MDS) or acute myeloid leukemia. MDS patients may promote the proliferation of immature cells and transform them into myeloid leukemia.
It should be emphasized that the total incidence of side effects of 1 is about 4.9%, which is not more or more serious than other drugs we use every day. 2. The basis of inducing leukemia cells is that patients have blood diseases. For us normal people, this possibility does not exist.
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